Glycerol-3-phosphate acyltransferase GPAT

Figure 2 presents glycerol-3-phosphate acyltransferase (GPAT) specific activities in purified mitochondrial and microsomal fractions for increasing palmitoyl-CoA / albumin ratios. For lowest ratios (lowest free palmitoyl-CoA concentrations), GPAT mitochondrial form was clearly more active than the microsomal form, with a notably lower apparent Km. The dramatic and specific inhibition of microsomal GPAT by N-ethylmaleimide... 

LPAAT - acyltransferase of lysophosphatidic acid GPAT - glycerol-3-phosphate acyltransferase DGAT - diacylglycerol acyltransferase PPA - phosphatase of phosphatidic acid. 

Figure 3.3 Enzyme systems associated with glycerolipid formation, (a) Glycerol kinase (EC 2.7.1.30) (b) glycerol-3-phosphate acyltransferase (EC 2.3.1.15) (GPAT) (c) 1-acyl-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) (LPAAT) (d) phosphatidate phosphatase (EC 3.1.3.4) (e) diacylglycerol acyltransferase (EC 2.3.1.20) (DAGAT) (f) cholinephosphotransferase (EC 2.7.8.2) (CPT) (g) 1-acylglycerophosphocholine acyltransferase (EC 2.3.1.23).

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