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Phosphatases phosphatidic acid

The synthesis of triacylglycerol takes place in the endoplasmic reticulum (ER). In liver and adipose tissue, fatty adds in the cytosol obtained from the diet or from de novo synthesis of palmitic add become inserted into the ER membrane. The reactions are shown in Fig. 13-10. Membrane-bound acyl-CoA synthetase activates two fatty acids, and membrane-bound acyl-CoA transferase esterifies them with glycerol 3-phosphate, to form phosphatidic acid. Phosphatidic acid phosphatase releases phosphate, and in the membrane, 1,2-diacylglycerol is esterified with a third molecule of fatty acid. [Pg.378]

How does chronic ingestion of ethanol lead to the development of a fatty liver, if you are told that ethanol stimulates the activity of phosphatidic acid phosphatase ... [Pg.397]

The stimulation of phosphatidic acid phosphatase by ethanol stimulates the production of diacylglycerol which in turn stimulates the synthesis of triacylglycerol. Therefore, the triacylglycerol concentration increases in the liver cells. [Pg.397]

Phosphatidic acid phosphatase Post proline cleaving enzyme Prostaglandin dehydrogenase Succinate dehydrogenase Sulfotransferase... [Pg.56]

Kai M, Wada I, Imai S, Sakane F, Kanoh H (1996) Identification and cDNA cloning of 35-kDa phosphatidic acid phosphatase (type 2) bound to plasma membranes. Polymerase chain reaction amplification of mouse H2O2-inducible hic53 clone yielded the cDNA encoding phosphatidic acid phosphatase. J Biol Chem 271 18931-18938... [Pg.43]

Roberts RZ, Morris AJ (2000) Role of phosphatidic acid phosphatase 2a in uptake of extracellular Upid phosphate mediators. Biochim Biophys Acta 1487 33-49... [Pg.45]

CTP phosphocholine cytidylyltransferase (3) glycerol kinase (4) acyl-CoA glycerol-3-phosphate acyltransferase (5) acyl-CoA acyl glycerol-3-phosphate acyltransferase (6) phosphatidic acid phosphatase (7) CDP-choline diacylglycerol phosphocholine transferase. [Pg.403]

FIGURE 21-2. Overview of lipoprotein metabolism. (ACAT = acyl CoAxholesterol acyltransferase CETP = cholesteryl ester transfer protein FA = fatty acid FFA = free fatty acid HMGR = HMG CoA reductase LCAT = lecithinxholesterol acyltransferase PAP = phosphatidic acid phosphatase). (From Ref. 17 with permission.)... [Pg.432]

NCEP National Cholesterol Education Program NHANES National Health and Nutrition Examination Survey NNT Number needed to treat PAP Phosphatidic acid phosphatase... [Pg.450]

The product is phosphatidic acid, itself an important substance (see page 31) and the starting point for the phosphatides and related lipids. The conversion of phosphatidic acid into triglyceride demands first the removal of the phosphate through hydrolysis by the enzyme phosphatidic acid phosphatase (an irreversible reaction). The product is diglyceride, which can react with a final fatty acyl-CoA to yield triglyceride (14,15) ... [Pg.182]

Phosphatidic acid phosphatase Membrane Phosphatidic acid... [Pg.82]

Fig. 5. Pathway depicting how flux through phosphatidylcholine (product of reaction 3) can promote acyl group diversity in plant triacylglycerols. Production of 18 2 (boxed) at the sn-2 position and its transfer to TG is used as a sample modification. Other fatty acid alterations may be substituted. Enzymes 1, glycerol-3-phosphate acyl-CoA acyltransferase and lysophosphatidic acid acyl-CoA acyltransferase 2, phosphatidic acid phosphatase 3, diacylglyceroliCDP-aminoalcohol aminoalcoholphosphotransferase 4, 18 l-desaturase or other fatty acid modifying enzyme 5, phosphlipid diacylglycerol acyltransferase 6, diacylglycerol acyltransferase 7, acyl-CoA phosphatidylcholine acyltransferase or phospholipase plus acyl-CoA synthetase. Fig. 5. Pathway depicting how flux through phosphatidylcholine (product of reaction 3) can promote acyl group diversity in plant triacylglycerols. Production of 18 2 (boxed) at the sn-2 position and its transfer to TG is used as a sample modification. Other fatty acid alterations may be substituted. Enzymes 1, glycerol-3-phosphate acyl-CoA acyltransferase and lysophosphatidic acid acyl-CoA acyltransferase 2, phosphatidic acid phosphatase 3, diacylglyceroliCDP-aminoalcohol aminoalcoholphosphotransferase 4, 18 l-desaturase or other fatty acid modifying enzyme 5, phosphlipid diacylglycerol acyltransferase 6, diacylglycerol acyltransferase 7, acyl-CoA phosphatidylcholine acyltransferase or phospholipase plus acyl-CoA synthetase.
Fig. 1. Phospholipid biosynthetic pathways in animal cells. The abbreviations are DHAP, dihydroxyacetone phosphate G-3-P, glycerol-3-phosphate PA, phosphatidic acid DG, diacylglycerol CDP-DG, cytidine diphosphodiacylglycerol PI, phosphatidylinositol PG, phosphatidylglycerol PG-P, phosphatidylglycerol phosphate DPG, diphosphatidylglycerol PP, phosphatidic acid phosphatase PE, phosphatidylethanolamine PC phosphatidylcholine PEMT, phosphatidylethanolamine A-methyltransferase CT, CTP phosphocholine cytidylyltransferase PS, phosphatidylserine CK/EK, choline/ethanolamine kinase CPT, CDP-choline 1,... Fig. 1. Phospholipid biosynthetic pathways in animal cells. The abbreviations are DHAP, dihydroxyacetone phosphate G-3-P, glycerol-3-phosphate PA, phosphatidic acid DG, diacylglycerol CDP-DG, cytidine diphosphodiacylglycerol PI, phosphatidylinositol PG, phosphatidylglycerol PG-P, phosphatidylglycerol phosphate DPG, diphosphatidylglycerol PP, phosphatidic acid phosphatase PE, phosphatidylethanolamine PC phosphatidylcholine PEMT, phosphatidylethanolamine A-methyltransferase CT, CTP phosphocholine cytidylyltransferase PS, phosphatidylserine CK/EK, choline/ethanolamine kinase CPT, CDP-choline 1,...
Fig. 2. Biosynthesis of phosphatidic acid (PA) occurs on both the endoplasmic reticulum (ER) and the outer membrane of mitochondria. The abbreviations are ACS, acyl-CoA synthetase, GPAT, glycerol-3-P acyltrans-ferase AGPAT, l-acylglycerol-3-P acyltransferase PP, phosphatidic acid phosphatase (lipin) PC, phosphatidylcholine PE, phosphatidylethanolamine TG, triacylglycerol. Fig. 2. Biosynthesis of phosphatidic acid (PA) occurs on both the endoplasmic reticulum (ER) and the outer membrane of mitochondria. The abbreviations are ACS, acyl-CoA synthetase, GPAT, glycerol-3-P acyltrans-ferase AGPAT, l-acylglycerol-3-P acyltransferase PP, phosphatidic acid phosphatase (lipin) PC, phosphatidylcholine PE, phosphatidylethanolamine TG, triacylglycerol.
Mouse Fid Phosphatidic acid phosphatase 1 (lipin-1) Impaired adipose development, insulin resistance, increased P-oxidation... [Pg.216]

Kudlaez, E. M, Navarro, H. A., Eylers, J. P., Dobbins, S. S Lappi, S. E., and Slotkin, T. A. (1989). Selective linkage of P-adnenergic receptors to functional responses in developing rat lung and liver Phosphatidic acid phosphatase, ornithine decaiboxylasc and lung liquid reabsorption. J. Dev. Physiol. 12, 129-134. [Pg.310]

Once phosphatidic acid is formed it can be converted to diacylglycerol by phosphatidic acid phosphatase. This is a key enzyme which, although catabolic, is involved in synthetic reactions-namely triacylglycerol, phosphoglyceride and glycosyl-glyceride formation. Phosphatidic acid phosphatase activity has been reported in various animal (Bell... [Pg.504]

See other pages where Phosphatases phosphatidic acid is mentioned: [Pg.130]    [Pg.45]    [Pg.251]    [Pg.110]    [Pg.804]    [Pg.805]    [Pg.554]    [Pg.446]    [Pg.364]    [Pg.131]    [Pg.64]    [Pg.154]    [Pg.45]    [Pg.251]    [Pg.379]    [Pg.380]    [Pg.804]    [Pg.805]    [Pg.107]    [Pg.108]    [Pg.213]    [Pg.217]    [Pg.285]    [Pg.459]    [Pg.98]    [Pg.16]    [Pg.147]    [Pg.135]    [Pg.135]   
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