Cancer susceptibility

Oxidative stress, DNA repair, and cancer susceptibility. Cancer Detect. Prev. 14, 555-561. 

There appears to a be a family prostate cancer syndrome and genome-wide scans have identified potential prostate cancer susceptibility loci on chromosomes 1, 2q, 12p, 15q, 16p, and... 

Miki, Y., et al., "A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1," Science, 266, 66-71 (1994). 

Mohrenweiser, H.W. and I.M. Jones, "Variation in DNA Repair is a Factor in Cancer Susceptibility A Paradigm for the Promises and Perils of Individual and Population Risk Estimation " Mutat. Res., 400, 15-24 (1998). 

Schrauzer, G.N., Effects of selenium antagonists on cancer susceptibility New aspects of chronic heavy metal toxicity, J UOEH 9, 208, 1987. 

To identify environmental exposures which alter penetrance of cancer susceptibility genes and to quantify these gene-environment interactions. 

J. G. Hengstler, M. Arand, M. E. Herrero, F. Oesch, Polymorphism of A-Acetyltransfe-rase, Glutathione S-Transferases, Microsomal Epoxide Hydrolase and Sulfotransferase Influence on Cancer Susceptibility , Recent Results Cancer Res. 1998, 154, 47 - 85. 

Shattuck-Eidens, D., et al., A collaborative survey of 80 mutations in the BRCAl breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening. Jama, 1995, 273(7), 535-41. 

Ho, A., Wakeham, A, Itie, A., Khoo, W., Fukumoto, M., and Mak, T.W., 1998, High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. S 1169-1178. 

Kinzler KW, Vogelstein B (1997) Cancer-susceptibility genes. Gatekeepers and caretakers. Nature... 

Weidman, J.R., Dolinoy, D.C., Murphy, S.K. and Jirtle, R.L. (2007) Cancer susceptibility Epigenetic manifestation of environmental exposures. Cancer Journal (Sudbury, Mass), 13, 9-16. 

Andrew AS, Nelson HH, Kelsey KT et al. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis 2006 27 1030—1037. 

Kolodner, R.D. (1995) Mismatch repair mechanisms and relationship to cancer susceptibility. Trends Biochem. Sci 20, 397-401. 

Prasad, V., Boivin, G. P., Miller, M. L., Liu, L. H., Erwin, C. R., Warner, B. W., and Shull, G. E., 2005, Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility. Cancer Res, 65 8655-61. 

McGrath M, Hankinson SE, Arbeitman L, Colditz GA, Hunter DJ, De Vivo I. Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility. Carcinogenesis 2004 25 559-565. 

Gibbs M, Stanford JL, Mclndoe RA, Jarvik GP, Kolb S, Goode EL, Chakrabarti L, Schuster EF, Buckley YA, Miller EL, Brandzel S, Li S, Hood L, Ostrander EA. Evidence for a rare prostate cancer-susceptibility locus at chromosome lp36. Am J Hum Genet 1999 64 776-787. 

Hengstler JG, Van Der Burg B, Steinberg P, Oesch F. Interspecies differences in cancer susceptibility and toxicity. Drug Metab Rev 1999 31 917-70. 

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