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Gastrointestinal tract medication

Sucralfate [54182-58-0] an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication (59). Bis- and tris-platinum complexes of sucrose show promise as antitumor agents (60). Sucrose monoesters are used in some pharmaceutical preparations (21). A sucrose polyester is under evaluation as a contrast agent for magnetic resonance imaging (mri) (61). Oral adrninistration of this substance opacifies the gastrointestinal tract and eliminates the need for purging prior to mri. [Pg.6]

Gastrointestinal Tract. The gastrointestinal (Gl) tract is the most familiar and widely used portal for dmg dehvery, largely because of the ease with which medications can be administered. [Pg.140]

In severe cases, or those refractory to treatment, truncal and limb weakness may be accompanied by involvement of masticatory, bulbar, and respiratory muscles. However the most life-threatening clinical manifestations are those affecting the gastrointestinal tract, since stomach ulceration can occur and death from perforation and peritonitis are not unknown. Medication with steroidal antiinflammatory agents is necessary but weakens the childrens resistance to infection, so that systemic spread of usually self-limiting disorders, such as candidiasis, may occasionally occur. [Pg.325]

C16-0027. Barium sulfate is a relatively insoluble salt used for medical radiographs of the gastrointestinal tract BaSOq (.S ) Ba " (a g) + SOq (a q) The concentration of Ba " ions in a... [Pg.1180]

Amphotericin B is particularly effective against systemic infections caused by C. albicans and Cryptococcus neoformans. It is poorly absorbed from the gastrointestinal tract and is thus usually administered by intravenous injection under strict medical supervision. Amphotericin B methyl ester (Fig. 5.15C) is water-soluble, unlike amphotericin B itself, and can be administered intravenously as a solution. The two forms have equal antifungal activity but higher peak serum levels are obtained with the ester. Although the ester is claimed to be less toxic, neurological effects have been observed. An ascorbate salt has recently been described which is water-soluble, of similar activity and less toxic. [Pg.114]

Finally be aware of the fact that diseases in the upper part of the gastrointestinal tract are common in the elderly and can cause severe complications and even be fatal. Drugs that are often used in the elderly due to chronic diseases with inflammation and pain are often the cause of gastritis, peptic ulcers and hiatus hernia. The risks of medication side effects as a reason for the problem must be taken into account when treating elderly for peptic ulcers and stomach pain. [Pg.58]

The direct transport of absorbed drugs into systemic circulation, effectively by-passing the first-pass effect of the liver and gastrointestinal tract Lower enzymatic activity compared to the gastrointestinal tract or liver Amenability to self-medication, which increases patient compliance Possibility of pulsatile delivery of some drugs to simulate the biorhythmic release of these drugs Lower risk of overdosage Achievement of controlled release... [Pg.113]

Enterotoxigenic E. coli (ETEC) is the main cause of TD in Latin America, whereas in Asia it is reported in only 15% of cases. Enteroinvasive E. coli (EIEC) strains are recorded with even less frequency. ETEC is isolated in 0 to 5% of cases. Symptoms of poisoning develop after 16 hours from consumption of contaminated water, salads, cheeses, or meats. The outgrowth of ETEC rods takes place in a patient s gastrointestinal tract, where they produce thermostable and thermolabile toxins that imitate Vibrio cholerae infections. Stimulation of intestinal guanylcyclase and interruption of ion transport leads to watery stools, which do not require medical treatment or only need simple replacement of fluids and salts by means of multielectrolyte solutions. If a co-infection with EIEC strains occurs, the symptoms of enteritis will develop, with the presence of leukocytes, erythrocytes, and mucous in stools due to a cytotoxic influence of bacteria (Butterton and Claderwood, 2001). [Pg.337]

The most common way to take medications is by mouth (orally). This is the slowest and least efficient way to get medication into your system. When a tablet or capsule is swallowed, much of it either passes through the gastrointestinal tract without ever being absorbed into the bloodstream or is inactivated by the liver before it has a chance to reach the rest of the body (more on this later). The fastest and most efficient means to get medication into the bloodstream is to inject it directly into a vein (intravenously). If oral medication is so much slower and so much less efficient, then why do we usually take our medications by mouth We do so because it is easier, cheaper, safer, and painless to take medications orally. [Pg.24]

Mushroom poisoning requires serious medical intervention because muscarine absorbs well in the gastrointestinal tract, and therefore it can lead to death. Muscarine is considerably more powerful than acetylcholine, possibly because of its high stability. Because it is... [Pg.183]

Therapy is perfectly adequate with simple iron salts (Table 2). In adults ferrous gluconate, fumarate or sulphate are all of proven equal efficiency. Approximately 50 mg of iron is present in each tablet with the remaining 300 mg made up with an inert filler. These are given on an empty stomach at least twice a day but should nausea prevail they can be taken with food. Absorption of slow release preparations is not recommended since iron is detached from the carrier beyond the main areas of absorption in the duodenum or jejunum. Stools turn black in all cases and this is a useful index of patient compliance. In 25% of individuals gastrointestinal tract side effects are encountered in the form of diarrhoea or constipation and patients will often spontaneously discontinue medication. It is therefore essential that a tablet-count be carried out on a regular basis with a substitute being provided when this first-line medication is intolerable. In children the same preparations are favoured as syrups these are given twice... [Pg.731]

The thyroid hormones T4 and T3 contain 65% and 59% of iodine respectively as an essential component for biological activity of the molecule. Iodine from dietary sources or medication enters the body via gastrointestinal tract. The recommended daily adult intake is 150-300 pg. Iodine is rapidly absorbed and enters the extracellular fluid pool. Iodide is removed from the blood largely by the thyroid and kidneys. The higher the intake the lower the fractional iodine uptake by the thyroid. [Pg.758]

Nausea is a common early side effect of all SSRIs. Early nausea is probably attributable to the stimulation of serotonin type 3 (5-HT3) receptors in the gastrointestinal tract, which downregulate after several weeks of treatment. Hence this side effect is both dose dependent and transient. Some patients report less nausea if they take the medication with food. Although rarely needed, medication that blocks the 5-HT3 receptor (e.g., ondansetron) can be used to reduce SSRI-induced nausea. [Pg.24]

Sustained release preparations of potassium chloride have been widely used to overcome the gastrointestinal side effects following medication with enteric coated tablets. Such formulation techniques delay the rate of absorption and produce a slow release of potassium chloride during the passage through the gastrointestinal tract [1,2]. [Pg.34]

Medicinal chemists have used isosterism for the design of safe, effective drug substances for many years. During the development of anti-ulcer medications, for example, it was found that metiamide (38) greatly reduced acid secretion in the gastrointestinal tract by antagonizing H2-receptor sites. Its potential as auseful anti-ulcer medication was lessened by adverse effects caused by the thiourea moiety, a toxicophore (Table 4.1). This moiety is essential for H2-receptor blockade, but bestows toxicity. [Pg.97]

Following oral administration, furaltadone is well absorbed from the gastrointestinal tract. After administration to laying hens of a medicated feed containing 100 mg/kg each nitrofurazone, furazolidone, nitrofurantoin, and furaltadone for 7 days, residues of furaltadone in egg yolk showed a maximum concentration of 0.2 ppm (129). [Pg.73]

Problem/lnfluence of Medication. During the postoperative period, calcium and vitamin D supplements were reinstituted to facilitate bone formation. The patient, however, soon began to experience bouts of diarrhea, apparently as a side effect of the vitamin D supplements. Consequently, the vitamin D supplements were withdrawn, and only the calcium supplement was continued. Because metabolic by-products of vitamin D accelerate the absorption of calcium from the gastrointestinal tract, both agents should be administered together. This patient, however, was apparently unable... [Pg.472]


See other pages where Gastrointestinal tract medication is mentioned: [Pg.205]    [Pg.141]    [Pg.9]    [Pg.43]    [Pg.45]    [Pg.51]    [Pg.194]    [Pg.1]    [Pg.148]    [Pg.229]    [Pg.436]    [Pg.338]    [Pg.108]    [Pg.81]    [Pg.516]    [Pg.306]    [Pg.100]    [Pg.27]    [Pg.180]    [Pg.513]    [Pg.316]    [Pg.322]    [Pg.249]    [Pg.3]    [Pg.759]    [Pg.89]    [Pg.909]    [Pg.7]    [Pg.205]    [Pg.26]    [Pg.13]    [Pg.23]    [Pg.131]   
See also in sourсe #XX -- [ Pg.1905 ]




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Gastrointestinal tract

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