Gastric cancer prognosis

However, high levels of certain protease inhibitors correlate positively with enhanced metastatic potential. For example, high levels of the PA inhibitor, PAI-1, correlate directly with poor prognosis in human breast and gastric cancers (J2, Nl) and indeed correlate with uPA itself (Rl). 

Yonemura, Y., Ninomiya, I., Yamaguchi, A., Fushida, S., Kimura, H., Ohoyama, S., Miyazaki, I., Endou, Y., Tanaka, M., and Sasaki, T. (1991). Evaluation of immunore-activity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer. Cancer Res. 51, 1034—1038. 

Mizoshita T, Tsukamoto T, Nakanishi H, et al. Expression of Cdx2 and the phenotype of advanced gastric cancers relationship with prognosis. J Cancer Res Clin Oncol. 2003 129 727-734. 

Wang, L., Shi, G.G., Yao, J.C., Gong, W., Wei, D., Wu, T.T., Ajani, J.A., Huang, S., Xie, K. (2005). Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer. Gastric Cancer S,18-28. 

The expression of iNOS was evaluated in diffuse and intestinal adenocarcinoma tumor according to Lauren s gastric cancer classification. Gastric carcinomas of the diffuse type are associated with a poor prognosis compared with tumors of the intestinal type high iNOS expression was found but no difference existed between the two types of tumors. Moreover the expression of Fas, Bcl-xl, Bcl-2, Bax, active caspase-3, and Ki-67 was investigated but no significant correlation was found between these apoptosis-related proteins and iNOS expression (Van der Woude et al. 2002). 

Caenazzo, C., Onisto, M., Sartor, L., Scalerta, R., Giraldo A., Nitti, D. and Garbisa, S. (1998). Augmented membrane type 1 matrix metalloproteinase (MTl-MMP) MMP-2 messenger RNA ration in gastric carcinomas with poor prognosis. CUn. Cancer Res. 4, 2179-2186. 

Morbidity should not exceed 30%. Lethality is between 0-3%. The 5-year survival rate following RO resection in metastatic colorectal carcinoma is 20-40%, in neuroendocrine tumours 90-100%, in malignant melanoma 15-25%, and in breast cancer 10-30%. Prognosis is poor in metastasizing renal cell carcinoma and in gastric or pancreatic carcinoma. Both R1 and R2 resection worsen the prognosis to the same extent. 

Kijima Y, Ishigami S, Hokita S, et al. The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones. Cancer Lett. 2003 200 33-40. 

The majority of previous immunohistochemical studies on the lymph node micrometastasis of gastric and colorectal cancers have only discussed the relationship between the presence or absence of micrometastasis and the prognosis. However, in their comparative study of lymph node micrometastasis between 10 recurrent and 9 nonrecurrent colorectal cancer cases in the pNO stage, Sasaki et al. revealed that the greater the numbers of lymph node metastases and the more distant the lymph node metastases, the higher the recurrence rate, and they proposed the introduction of a concept of... 

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