Fungi pathogenicity

One of the special features of azole compounds is the abundance of synthetic possibilities and therefore the abundant selection opportunities for biology and medicine. By examination of the properties of azole derivatives, one can recognize other applications for them apart from the control of fungi pathogenic to plants and man. Some of the azole derivatives, such as lombazole, exhibit... 

High activity against fungi pathogenic to humans (dermatophytes, yeasts, biphasic fungi, molds)... 

Odstrcilova, L. (2006). Diversity of fungi pathogens incidence in the Czech traditional regions of caraway cultivation. In Book of Abstracts from 8th Conference of the European Foundation for Plant Patology, Coppenhagen, Denmark, p. 31. 

Fungi Pathogenic for Humans and Animals (in three parts), edited by Dexter H. Howard... 

Several related derivatives of imazalil (miconazole, econazole) show in vitro a broad antimicotic spectrum against fungi pathogenic to man and animals (Buchenauer, 1977c). 

Ciegler A., Burmeister H.R. and Vesonder R.F. (1983) Poisonous fungi mycotoxins and mycotoxicoses. In Howard D.H. (ed) Fungi pathogenic for humans and animals, Vol. 3, Part B. Dekker, New York, 413. 

Streptomyces sp. AK409 Pyrocoll Arthrobacter strains. Filamentous fungi, pathogenic protozoa, human tumor cell lines Dieter et al. (2003)... 

Fusarium nivale Ces Facultative fungi Pathogens Abiotic... 

Variotin, an antifungal antibiotic, is produced by Paecilomyces varioti Bainer var. antibioticus and was isolated by Takeuchi et al, (1959)- It does not inhibit bacteria and some fungi at 160 [xg/ml but does inhibit a number of fungi pathogenic to man such as Blastomyces dermatitidis, Trichophyton ruhrum and Microspomm audouini at 0.25 (xg/ml or less. It is used topically for the treatment of human dermatomycosis. 

Fungi are broadly associated microbial pathogens of insects. Beauveria bassiana is extensively used as a microbial insecticide in China and Eastern Europe, especially for the control of the com borer Ostrinia spp. However, fungi have had no significant development as microbial insecticides in the United States. 

Systemic mycoses are caused either by true pathogenic fungi (endemic in distinct areas of USA/South America) or by opportunistic fungi that induce severe infections in immunosuppressed patients. The arsenal for the treatment of deep organ mycoses is relatively small Amph B, 5FC, azoles (FLU, ITRA, voriconazole (NBA filing)) and CAS. 

Amphotericin B, is a polyene antibiotic, used in the therapy of systemic fungal infections. Its mode of action exploits differences in membrane composition between the pathogen and the human host. Ergosterol, the predominant sterol of fungi, plants, and some protozoan parasites, interacts with Amphotericin B, resulting in an increased ion permeability of the membrane. Humans contain cholesterol, which has a low affinity for amphotericin B. 

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