Fungi, pathogenic

Systemic mycoses are caused either by true pathogenic fungi (endemic in distinct areas of USA/South America) or by opportunistic fungi that induce severe infections in immunosuppressed patients. The arsenal for the treatment of deep organ mycoses is relatively small Amph B, 5FC, azoles (FLU, ITRA, voriconazole (NBA filing)) and CAS. 

For the evaluation of preparations to be used against pathogenic fungi, suitable cultures of these pathogens should be used. To test substances intended to inhibit general contaminants, cultures of common fungi obtained conveniently by exposing Petri dishes of solid media to the atmosphere may be used, or alternatively dust or soil may be used as a source of a mixed inoculum. 

Langfelder, K. et al., Biosynthesis of fungal melanins and their importance for human pathogenic fungi, Fungal Genet. Biol., 38, 143, 2003. 

M. A. L. Oedjijono and C. Dragar, Lsolation of bacteria antagonistic to a range of plant pathogenic fungi. Soil Biol. Biochem. 25 247 (1993). 

Conidia from pathogenic fungi that land on a plant surface carry low levels of cutinase to sense the contact with the host, and the cutin monomers generated upon contact of the conidia with the plant can be the inducers that allow the fungus to produce enough quantities of cutinase to gain access into the host (Fig. 12). This postulate was supported by many lines of evidence. Highly pa-... 

Culture Collection of Pathogenic Fungi and Actinomycetes (Chiba University Research Center for Pathogenic Fungi and Microbial Toxicoses). 

TABLE 3. Fungicidal activity (MIC values 2) of the Si/Ge analogues Flusilazole and 5 against plant and human pathogenic fungi (modified from Reference 26)... 

A number of plant pathogens, fungi, and bacteria are known to... 

Pranckeviciene et al.11 have assessed the NMR spectra of pathogenic fungi and of human biofluids, finding the spectral signature that comprises a set of attributes that serve to uniquely identify and characterize the sample. This use of GAs effectively reduces the dimensionality of the data, and it can speed up later processing as well as make it more reliable. 

De Lorenzo G, D Ovidio R, Cervone F (2001) The role of polygacturonase-inhibiting proteins (PGIPs) in defense against pathogenic fungi. Annu Rev Phytopathol 39 313-335... 

SH insect pathogenic fungi - Verticillium hemipterigenum Vertihemipteiiides A and B - diketopiperazines with antimicrobiai and cytotoxic activities 103... 

Rice piant pathogenic fungi Ustilaginoidea virens... 

Piant pathogenic fungi -Apiospora montagnei Sacc. TC 1093... 

---