Functionalized mesoporous nanoparticles

Thiol-functionalized mesoporous silicas not only serve as a basis for sulfonic acid-functionalized phases, but can be used for several other applications, for instance as adsorbents. Thiol-functionalized silicas can also be prepared as small nanoparticles with spherical morphologies by employing modified Stober reaction conditions.174 The high affinity of these compounds for thiophilic heavy metals, especially toxic Hg2+ ions, has been demonstrated by several authors.175-178... 

As an intermediate between solid supported layers and the inherent dynamic and nanostructured properties of phospholipid vesicle supports, silica and especially mesoporous silica nanoparticles may provide interesting platforms for dynamic bilayers. Previous studies have shown that stable bilayers can form on both amorphous [102] or functional silica [103, 104] and mesoporous nanoparticles [105] or membranes [106]. This type of biomimetic carrier has great potential as a type of trackable stabilized membrane capable of displaying cellular targeting elements in a close to natural configuration. 

Furthermore, mesoporous nanoparticles with a diameter of about 100 nm can be produced as shown in the upper part of Fig. 27.5b. We intend to use them as the basis for a novel drug delivery system which is sketched in the lower part of Fig. 27.5b. This system has several functions for controlled release and targeting of specific cells. These functions are (1) functionalized pore walls to create a depot effect and controlled release of the drug ... 

Fig. 27.5. Mesoporous silica nanoparticles as novel drug delivery systems, (a) Cocondensation method to form functionalized mesoporous silica structures in a surfactant template synthesis, (b) TEM image of mesoporous silica nanoparticles and sketch of a novel drug delivery particle which contains functionalized pores, closed by a gate, and is decorated with ligands for cell targeting, (c) Cell targeting by ligand-receptor interaction at the cell membrane, endosomal uptake and controlled release after pH change from early to late endosome...

Yu, J.-J., Lu, S., Li, J.-W., Zhao, F.-Q., and Zeng, B.-Z. 2007. Characterization of gold nanoparticles electrochemically deposited on amine-functionalized mesoporous silica films and electrocatalytic oxidation of glucose. Journal of Solid State Electrochemistry 11, 1211-1219. 

Functionalized mesoporous silica Material with tailored nanoparticles... 

Hirai and colleagues [368] also incorporated reverse microemulsion-mediated CdS nanoparticles in thiol-modified mesoporous silica, e.g. FM 41 (functionalized MCM-41) and FM 48 (functionalized MCM-48). For synthesis of CdS, the well-utilized reverse microemulsions containing AOT, isooctane and aqueous solutions of Cd(N03)2 or Na2S were mixed. In a few minutes after the formation of CdS, a functionalized mesoporous silica sample was added to the mixed microemulsion. The mix was stirred for 12 h and centrifuged for collection of the product. 

Three organically functionalized mesoporous silica nanoparticles, MSN-COOH, MSN-SOjH, and MSN-SH, were synthesized. TEOS and a corresponding organo-trimethoxysilane (10 mol% to the TEOS) were added dropwise to an aqueous solution... 

Synonims silicon dioxide untreated fume silica dimethyldichlorosilane functionalized silica nanoparticles mesoporous silica... 

Cho Y, Shi R, Borgenes R, Ivanisevic A (2008) Functionalized mesoporous silica nanoparticles-based drug delivery system to rescue acrolein-mediated cell death. Nanomedicine 3 507-519... 

Calixarene derivatives have also been used to functionalize mesoporous silica nanoparticles (MSNs) [102-105]. The macrocycle acts as a gatekeeper for the loading and release processes of the selected molecule. Host-guest interactions between sulfonato-calixarenes and positively charged moieties attached on the surface of MSNs allow controlling drug encapsulation and release process. 

Kobler, J., Moeller, K., and Bein, T. (2008) Colloidal suspensions of functionalized mesoporous silica nanoparticles. ACS Nano, 2 (4), 791-799. 

Brevet, D., Basile, I., Maynadier, M., Vaillant, O., Mongin, O., Blanchard-Desce, M., Morere, A., Garcia, M., Durand, J.-O., and Raehm, L. (2011) Mannose-functionalized mesoporous silica nanoparticles for efficient two-photon photodynamic therapy of solid tumors. Angew. Chem., Int. Ed., 50 (48), 11425-11429. 

W., Chen, L Wang, H., Mo, X., and Zhang, Y. (2013) Polyelectrolyte multilayer functionalized mesoporous silica nanoparticles for pH-responsive drug delivery layer thickness-dependent release profiles and biocompatibility. / Mater. Chem. B, 1 (43), 5886-5898. 

He, X., Zhao, Y., He, D., Wang, K., Xu, F., and Tang, J. (2012) ATP-responsive controlled release system using aptamer-functionalized mesoporous silica nanoparticles. Langmuir, 28 (35), 12909-12915. 

Sanchez A, Morante-Zarcero S, Perez-Quintanilla D, Sierra I, del Hierro I (2010) Development of screen-printed carbon electrodes modified with functionalized mesoporous silica nanoparticles application to voltammetric stripping determination of Pb(II) in non-pretreated natural waters. Electrochrm Acta 55 6983-6990... 

Mann and coworkers proposed a unique method to prepare nanohybrids of mesoporous silica and gold nanoparticles mediated by programmed DNA hybridization, as illustrated in Figure 4.21 [186], MCM-41 nanoparticles were first functionalized with a 3 -amino-terminated 12-base single strand oligonucleotide... 

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