FUDR - Floxuridine

Ftorocort Triamcinolone acetonide F. T.R. Tegafur Fua Med - Nitrofurantoin FUDR - Floxuridine... 

Floxuridine (FUDR) Fludarabine Phosphate (Flamp, Fludara)... 

FUdR, or floxuridine, is converted by thymidine or deoxyuridine phosphorylases into 5-FU. It is therefore not surprising that the pharmacology and toxicity of both agents are similar. Hoxuridine is also administered parenterally, since oral absorption is unpredictable and incomplete. It is primarily used... 

Floxuridine (FUDR) is the nucleoside of 5-fluo-rouracil that is readily converted into 5-fluorouracil in vivo. It has similar pharmacological effects but is preferred to 5-fluorouracil for hepatic arterial infusions because it is more extensively metabolized in the liver than 5-fluorouracil, with less systemic toxicity. 

Clofarabine (Clolar) Cytarabine [ARA-C] (Cytosar-U) Cytarabine Liposome (DepoCyt) Floxuridine (FUDR) Fludarabine Phosphate (Flamp, Fludara)... 

FLUORINECOMPOUNDS,ORGANIC - FLUORINATED AROMATIC COMPOUNDS] (Vol 11) Floxuridine USP (FUDR) [50-91-9]... 

Floxuridine FUDR Carcinoma of the Gl tract and liver Gl disorders [nausea, vomiting, loss of appetite] skin disorders [discoloration, rash, hair loss]... 

Fluorouracil and fluorodeoxyuridine (floxuridine) inhibit pyrimidine nucleotide biosynthesis and interfere with the synthesis and actions of nucleic acids. To exert its effect, fluorouracil (5-FU) must first be converted to nucleotide derivatives such as 5-fluorodeoxyuridylate (5-FdUMP). Similarly, floxuridine (FUdR) is also converted to FdUMP by the following reactions ... 

Fluorouracil is normally given intravenously (Table 55-3) and has a short metabolic half-life on the order of 15 minutes. It is not administered by the oral route because its bioavailability is erratic due to the high levels of the breakdown enzyme dihydropyrimidine dehydrogenase present in the gut mucosa. Floxuridine (5-fluoro-2 -deoxyuridine, FUDR) has an action similar to that of fluorouracil, and it is only used for hepatic artery infusions. A cream incorporating fluorouracil is used topically for treating basal cell cancers of the skin. 

SYNS DEOXYFLUOROURIDINE l-p-d-2 -DEOXYRIBOFURANOSYL-5-FLUOROURACIL FDUR FLOXURIDIN FLOXURIDINE FLUORODEOXY-URIDINE p-5-FLUORO-2 -DEOXYURIDINE 5-FLUORODEOXYURIDINE 5-FLUORO-2-DEOXY-URIDINE 5-FLUORO-2 -DEOXYURIDINE 5-FLUOROURACIL DEOXYRIBOSIDE 5-FLUORO-URACIL-2 -DE0XYRIB0SIDE FLUORURIDINE DEOXYRIBOSE FUDR 5-FUDR NSC-27640 RO 5-0360... 

Aldrighetti L, Arm M, Ronzoni M, Salvioni M, Villa E, Ferla G. Extrahepatic biliary stenoses after hepatic arterial infusion (HAI) of floxuridine (FUdR) for liver metastases from colorectal cancer. Hepatogastroenterology 2001 48(41) 1302-7. 

Floxuridine (FUdR) FUdR (fluorodeoxyuridine FUDR) is used primarily by continuous infusion into the hepatic artery for treatment of metastatic carcinoma of the colon or following resection of hepatic metastases, the response rate to such infusion is 40 to 50%, or double that observed with intravenous administration. Intrahepatic arterial infusion for 14 to 21 days may be used with minimal systemic toxicity. However, there is a significant risk of biliary sclerosis if this route is used for multiple cycles of therapy. Treatment should be discontinued at the earliest manifestation of toxicity (usually stomatitis or diarrhea) because the maximal effects of bone marrow suppression and gut toxicity will not be evident until days 7 to 14. 

FU, floxuridine (5-fluoro-2 -deoxyuridine, or 5-FUdR), aTK/idoxuridine (5-iodo-deoxyuridine) (see Chapter 49). lododeoxyuridine behaves as an analog of thymidine, and its primary biological action results from its phosphorylation and ultimate incorporation into DNA in place of thymidylate. In 5-FU, the smaller fluorine allows the molecule to mimic uracil biochemically. However, the fluorine-carbon bond is much tighter than that of C—H and prevents the methyla-tion of the 5 position of 5-FU by TS. Instead, in the presence of the physiological cofactor 5,... 

FIGURE 51-5 Activation pathways for 5 fluorouracil (5-FU) and 5-floxuridine (FUR). FUDP, floxuridine diphosphate FUMP, floxuridine monophosphate FUTP, floxuridine triphosphate FUdR, fluorodeoxyuridine FdUDP fluorodeoxyuridine diphosphate FdUMP fluorodeoxyuridine monophosphate FdUTP fluorodeoxyuridine triphosphate PRPP 5-phosphoribosyl-1 -pyrophosphate. 

In the USA, SIRT was approved for the treatment of unresectable primary hepatic malignancies and metastases from colorectal cancer together with intrahepatic artery chemotherapy (IHAC) using floxuridine (FUDR). Nevertheless, worldwide SIRT may be used in patients with hepatic malignancies originating from various primaries, such as neuroendocrine tumors, breast, colorectal, and bronchial cancer, where the disease appears to be limited to the liver and other treatment options are no longer available. 

An alternative activation pathway involves the thymidine phosphorylase catalysed conversion of 1 to Floxuridine (FUDR, 4), which is then phosphorylated by thymidine kinase to give 19. The metabolite of 1 - Floxuridine - is itself used as an anti-cancer agent [9]. It was launched in 1970 by Hospira hic [5]. Upon rapid injection, most of Hoxuiidine is catabolized to Fluorouracil hence similar effects on the organism are obtained in this case. On the contrary, when 4 is slowly administered into the arterial blood, it is mostly transformed to 19 thus toxic effects are diminished comparing to 1 [10]. 

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