Intrahepatic artery chemotherapy

In the USA, SIRT was approved for the treatment of unresectable primary hepatic malignancies and metastases from colorectal cancer together with intrahepatic artery chemotherapy (IHAC) using floxuridine (FUDR). Nevertheless, worldwide SIRT may be used in patients with hepatic malignancies originating from various primaries, such as neuroendocrine tumors, breast, colorectal, and bronchial cancer, where the disease appears to be limited to the liver and other treatment options are no longer available. 

Agarwala SS, Panikkar R, Kirkwood JM (2004) Phase I/II randomized trial of intrahepatic arterial infusion chemotherapy with cisplatin and chemoembolization with cisplatin and polyvinyl sponge in patients with ocular melanoma metastatic to the liver. Melanoma Res 14 217-222... 

Fiorentini G, Poddie DB, Giorgi UD et al (2000) Global approach to hepatic metastases from colorectal cancer indication and outcome of intra-arterial chemotherapy and other hepatic-directed treatments. Med Oncol 17 163-173 Goldberg SN, Gazelle GS, Compton CC, Mueller PR, Tanabe KK (2000) Treatment of intrahepatic malignancy with radiofrequency ablation radiologic-pathologic correlation. Cancer 88 2452-2463... 

Tanada M et al. (1996) Intrahepatic arterial infusion chemotherapy for the colon cancer patients with liver metastases - a comparison of arterial embolization chemotherapy versus continuous arterial infusion chemotherapy. Gan To Kagaku Ryoho 23 1440-1442... 

A patient who received regional intrahepatic chemotherapy from a continuous infusion pump for 31 months developed a gastroduodenal artery-duodenal fistula, and presented with signs and symptoms of upper gastrointestinal bleeding. 

Pajkos G et al. (1998) Combined therapy of metastatic liver neoplasms intrahepatic chemoembolization and systemic chemotherapy. Orv Hetil 139 1013-1017 Parkin DM et al. (1999) Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80 827-841 Patt YZ et al. (1994) Hepatic arterial infusion of floxuridine, leucovorin, doxorubicin, and cisplatin for hepatocellular carcinoma effects of hepatitis B and C viral infection on drug toxicity and patient survival. J Clin Oncol 12 1204-1211... 

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