Frontal white matter

Durazzo et al. (2004) 21 29 NA 6 25 Among recovering alcohohcs, smokers had lower frontal white matter NAA and lower midbrain Cho than nonsmokers. Severity of nicotine dependence and number of cigarettes per day were negatively correlated with thalamic and lenticular NAA. Smoking also was associated with lower midbrain NAA and Cho and with lower Cho in cerebellar vermis. 

Immunostaining for BrdU and markers for immature migrating neurons (PSA-NCAM, /3111-tubulin or Doublecortin) in frontal white matter did not reveal chains... 

You can activate the brain in sleep in whatever way you like, but you will not produce the psychological experience of dreaming without activating the parietal cortex or deep frontal white matter. Why not Are these restricted and discrete brain regions the brain s seats of dreaming Probably not. More likely they constitute connections allowing other brain regions to communicate with one another in such a way as to sustain dream consciousness. 

Kumra S, Ashtari M, McMeniman M, et al. 2004. Reduced frontal white matter integrity in early-onset schizophrenia A preliminary study. Biol Psychiatry 55 1138-1145. 

Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, et al. 2002. Frontal white matter, aggression and impulsivity in men with schizophrenia. Biol Psychiatry 52 9-14. 

Rusch N, Spoletini I, Wilke M, Martinotti G, Bria P, et al. 2008. Inferior frontal white matter volume and suicidality in schizophrenia Psychiatry Res Neuroimaging 164 206-214. 

Interstitial edema is seen in the periventricular regions in patients with hydrocephalus (Fig. 9). The widened extracellular space is the site of transependymal flow of CSF. The movement of ISF into the frontal white matter leads to difficulty walking and incontinence in the syndrome of normal pressure hydrocephalus. 

In that study, NAA, Cho and Cr were measured in frontal white matter (FWM), parietal white mater (PWM) and the thalamus of the eight full-term neonates with hypothyroidism. They were 5-7 days of age, and were born to mothers living in iodine-deficient areas. Their mothers had not received iodine supplementation in the pregestational or gestational period. A repeat MRS examination was performed after 8 weeks of thyroxine therapy. Metabolite levels of these patients were compared to levels obtained from eight full-term age-matched healthy neonates of mothers who had been using iodine-supplemented salt since the pregestational period. 

Table 65.4 Brain MRS findings obtained from frontal white matter, parietal white matter and the thalamus in neonates with hypothyroidism and healthy neonates (mean SD) ...

A (right frontal, white matter glioma)... 

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