Iodine-deficient area

Iodine-induced hyperthyroidism People living in iodine-deficient areas people with a... 

The observation that Canada, with ample nutritional iodine, has a relatively high rate of lithium-related hypothyroidism compared with relatively low rates in iodine-deficient countries such as Italy, Spain, and Germany led to the suggestion that ambient iodine may play a role in the genesis of this condition (270). This is reminiscent of the association of amiodarone with hypothyroidism or hyperthyroidism in iodine-replete and iodine-deficient areas respectively (SEDA-10,148). 

To assess a local populations iodine status, according to the WHO requirements, by measurement of Ul and estimation of nutritional iodine intake and TGP, we used a comprehensive scheme to evaluate iodine status (Brauer et al., 2005) in Leipzig, a previously iodine-deficient area (Gruning et al., 2001 Hampel et al., 1995). We combined the investigation of different sources of iodine and different... 

A history of benign thyroid diseases, mostly goiter and nodules, and long-term residency in iodine-deficient areas have now been considered as established risk factors for thyroid cancer. Pathogenesis of thyroid disease is associated with several genetic alterations. 

Yavuz et al. (2004) investigated the relationship between Fe status and thyroid hormones in adolescents living in an iodine-deficient area. The purpose was to evaluate the effect of Fe status on the thyroid hormone profile in adolescents living in a mildly iodine-deficient area in Turkey. 

Table 53.8 Crude incidence of thyroid cancer in iodine-deficient areas...

A third study (Remer et al, 1999), in an iodine-deficient area of Germany, found low mean urinary levels in both... 

A study performed in an iodine-deficient area of Sweden (Abdulla et al, 1981) found the vegan diet to be iodine-deficient, but did not consider the iodine content of an omnivore diet from that iodine-deficient region. 

In a severely iodine-deficient area of Morocco, TPO-Ab and Tg-Ab were measured in 323 schoolchildren before... 

In a cross-sectional study from a borderline iodine-deficient area in Denmark (Copenhagen), Knudsen et al. included 2656 randomly selected subjects aged 41—71 years. The prevalence rate of TPO-Ab, measured by ELISA, was high at 22.8% (Knudsen et al.y 1999). 

A number of studies on the epidemiology of thyroid autoantibodies have been performed as descriptive studies in iodine-deficient areas. Results from some population-based studies from both iodine-deficient and iodine-sufficient areas are shown in Table 60.1. The results are ambiguous. 

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