Formic acid.hydrochloride

In principle, aspartame is produced through the coupling of two amino acid moieties. One moiety consists of T.-phenylalanine methyl ester hydrochloride (2) made by treating the amino acid ia methanol and hydrochloric acid the other is aspartic acid anhydride hydrochloride or formic acid salt. The coupling reaction generates two positional isomers, a and p. 

Shifts in the SEC fractionation range are not new. It has been known for decades that adding chaotropes to mobile phases causes proteins to elute as if they were much larger molecules. Sodium dodecyl sulfate (SDS) (9) and guanidinium hydrochloride (Gd.HCl) (9-12) have been used for this purpose. It has not been clearly determined in every case if these shifts reflect effects of the chaotropes on the solutes or on the stationary phase. Proteins are denatured by chaotropes the loss of tertiary structure increases their hydrodynamic radius. However, a similar shift in elution times has been observed with SEC of peptides in 0.1% trifluoroacetic acid (TEA) (13-15) or 0.1 M formic acid (16), even if they were too small to have significant tertiary structure. Speculation as to the cause involved solvation effects that decreased the effective pore size of the... 

The Leuckart synthesis has been applied successfully in the thiophene series, iV,A -Dimethyl thenylamine and A, A -diethyl thenylamine were obtained from 2-thiophenealdehyde and the appropriate for-mamide. Seven -(2-thienyl)- -arylethylamine hydrochlorides have been prepared from the corresponding ketones in about 40-60% yields and, finally, A -methyl-1-(3-thienyl)-2-propylamine was obtained in 48% yield in the Leuckart reaction from 3-thienylace-tone, methylamine, and formic acid. ... 

CH4N2 463-52-5) see Itraconazole formamidine hydrochloride (CH5QN2 6313-33-3) sec Allopurinol 7-formamidocephalosporanic acid (CiiHj2N20fiS 27267-35-2) see Cefamandole 2-(2-formamido-4-thiazolyl)-2-methoxyiminoacetic acid (C7H7N3O4S 83594-38-1) see Ceftizoxime (2-formamidothiazol-4-yl)oxoacetic acid (CfiH4N204S 64987-06-0) see Cetixime formic acid... 

Isobutyl chloroformate Formic acid, chloro-, isobutyl ester (8) Carbonochloridic acid, isobutyl ester (9) (543-27-1) S-tcrf-Butyl-L-cysteine ferf-butyl ester L-Cysteine, S-(l,l-dim-ethylethyl), 1,1-dimethylethyl ester (9) ( —) acetate (38024-19-0) hydrochloride (2481-11-0)... 

Aqueous HCI solutions hydrolyze the P-N bond to give the amine hydrochloride and R2P-OH, which then disproportionates and is oxidized to diphenylphosphinic acid. A free phosphinous amide anion, with the countercation complexed by a crown ether, has been shown to be hydrolyzed and oxidized to the corresponding phosphinite with unusual ease [119]. Formic acid in toluene can be utilized for converting P,P-disubstituted phosphinous amides into their respective phosphane oxides [30]. 

Fermentation, 22, 53 Ferric nitrate, 23, 20 Fieser s solution, 21, 110 Filter fabric, Pyrex glass, 22, 33, 65 Vinyon, 22, 33, 67 Filter paper, hardened, 22, 45 Fischer indole synthesis, 22, 98 Flash distillation, 21, 85 Flask, modified Claisen, 22, 11 Fluorescence of 9-aminoacridine hydrochloride, 22, 7 Formaldehyde, 20, 60 Formalin, 22, 66 Formic acid, 20, 66, 102 23, 43 Formic acid, chloro-, benzyl ester, 23, 13... 

At the same time the formaldehyde (as hydrate) is dehydrogenated yielding formic acid and COs. If the amount of aldehyde is increased trimethylamine hydrochloride is produced in an analogous manner. 

NTO Semicarbazide hydrochloride, Formic acid, Nitric acid... 

The trimethylamine may be generated by the action of alkali on trimethylamine hydrochloride and dissolved in acetone. The submitter prepared trimethylamine by the method of Som-melet and Ferrand and obtained a 65% yield by the interaction of ammonia, formaldehyde, and formic acid. The checkers found that a commercial 25% solution of trimethylamine in methanol (210 ml.) gave the same yields as the acetone solution. 

Mercury fulminate is relatively resistant to the action of dilute acids, in particular to that of nitric acid, but concentrated acids cause decomposition. Thus, under the influence of nitric acid decomposition occurs with evolution of NO, CO, acetic acid and mercuric nitrate. Under the influence of concentrated hydrochloric acid free fulminic acid is evolved (with an odour resembling that of hydrogen cyanide) as well as the decomposition products hydroxylamine hydrochloride, formic acid, mercuric chloride (Carstanjen and Ehrenberg [32] Scholl [33]). Mercury fulminate explodes on direct contact with concentrated sulphuric acid. 

Condensation reactions of aniline and of other bases with aromatic aldehydes to give Schiff s bases are accelerated by ultraviolet light in buffered media. For example, o-phenylenediamine reacts with formic acid to yield benzimidazole and acetylacetone reacts with guanidine to form 2-amino-4,6-dimethylpyrimidine.162 Similarly, lobelanine is formed by the photocondensation of glutaraldehyde, benzoylacetic acid, and methylamine hydrochloride.163... 

TheN-monomethylandtheN,N-dimethylhomologuesof2C-Dhavebeen synthesized from 2C-D. The N-monomethyl compound was obtained by the quatemization of the Schiff s base formed between 2C-D and benzaldehyde with methyl sulfate, followed by hydrolysis the hydrochloride salt had a melting point of 150-151 °C,fromEtOH. The N,N-dimethyl compound resulted from the action of formaldehyde-formic acid on 2C-D the hydrochloride salt had a melting point of 168-169 °C from EtOH/ether. These two compounds were some ten times less effective in interfering with conditioned responses in experimental rats. There is no report of their having been explored in man. 

Conditions for effecting this conversion in one step have been described.65 The method involves heating a mixture of the aldehyde, hydroxylamine hydrochloride, sodium formate and formic acid and the reaction is considered to proceed through the intermediate formation of an oxime formate. 

Only one gas chromatographic method has been reported to determine CCA in human plasma samples [53]. The standard metabolite used was the hydrochloride salt of CCA, while an analogous hydrochloride salt of the carboxylic acid was used as internal standard. Extraction by LLE method followed by SPE, and subsequent derivatization, was used to extract the metabolite of clopidogrel from human plasma and serum since this procedure could minimize matrix effects. In the LLE procedure, formic acid and diethyl ether were used to extract the analyte, followed by an SPE extraction of the residue in methanol using a Cis SPE column. 

Pentazocine is identified in the combination product pentazocine hydrochloride and aspirin tablets by a method given in Addendum a, 2nd Supplement of USP XX. A silica gel TLC system is used with the solvent system ethyl acetate methanol formic acid (90 5 5). Detection is by UV, iodine vapor and iodoplatinate spray (4). 

A mixture of 61 grams l-phenyl-l-oxo-2-(N-methyl-N-ethanolamino)-propane hydrochloride and 100 cc 98-100% formic acid was refluxed at the boiling point at atmospheric pressure for 45 minutes on an oil bath. Thereafter, the oil bath temperature was increased to 180°C and as much of the excess unreacted formic acid as possible was distilled off. A vigorous evolution of carbon dioxide developed during the distillation, which ceased after approximately 45 additional minutes. The honey-yellow syrup which remained as the distillation residue was worked up by admixing it with about six volumes of water and adjusting the aqueous mixture to alkaline reaction with concentrated sodium hydroxide. An oily phase separated out which was extracted with ether. The ether extract was washed with water and dried over potassium carbonate. The solvent was distilled off and the distillation residue was fractionally distilled in vacuo. The base boils at 132°-133°C at 12 mm. The yield was 93% of theory. Reaction with tartaric acid gave the final product. 

A mixture of 3.5 grams (0.013 mole) of the above a,a-diphenyl-alpha-(2-piperidyl)methanol, 4 g (0.05 mole) of formaldehyde (37%), and 6 grams (0.1 mole) of formic acid was refluxed for 2 days. The reaction mixture was treated with 1.3 g (0.013 mole) of cone, hydrochloric acid and vacuum distilled on the steam bath. The residue was recrystallized from butanone to give the a,a-diphenyl-alpha-(2-piperidyl)methanol hydrochloride which melted at 228-229°C (dec.). 

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