Pentazocine hydrochloride

Benzomorphan derivatives pentazocine hydrochloride pentazocine lactate... 

Two different interconvertible crystal polymorphs of pentazocine hydrochloride are known with melting points of 218° and 254° (2,21). 

Results of elemental analysis for pentazocine and pentazocine hydrochloride are shown in Table 3. 

Fig. 5. H nuclear magnetic resonance spectrum of pentazocine hydrochloride.

The dissolution method for pentazocine hydrochloride tablets utilizes a UV determination of pentazocine in filtered test samples at 278 nm. The apparatus used is USP number two at 50 rpm with water as the dissolution medium. The solutions are measured in hydrochloric acid diluted with dissolution medium to give 0.01 N HC1 and quantitatively compared to a suitable standard (46). 

A dissolution procedure for pentazocine hydrochloride and aspirin tablets is set forth in Addendum a, Second Supplement to the USP XX. The procedure is carried out with apparatus number one at 80 rpm using water as the dissolution medium. 

Pentazocine is identified in the combination product pentazocine hydrochloride and aspirin tablets by a method given in Addendum a, 2nd Supplement of USP XX. A silica gel TLC system is used with the solvent system ethyl acetate methanol formic acid (90 5 5). Detection is by UV, iodine vapor and iodoplatinate spray (4). 

The stability of repackaged pentazocine hydrochloride injection was studied to determine the expiration date. An extrapolation of the Arrhenius plot obtained using 40°, 50°and 60° rate constants gave a k of 5 4-4-8 x 10-5 day- at 25°. This meant that a 10% loss of potency occurred in 1909 days at 25° (4-8). 

Ultraviolet Spectrophotometry Pentazocine can be determined in pentazocine hydrochloride tablets by a UV spectral method. The sample is extracted with sulfuric acid, basified, extracted with ether and back-extracted into 1 in 70 dilute sulfuric acid. The absorbance of the solution in 0.5 N H2SO1L is determined at 278 nm and compared to that of the standard preparation. A cation exchange column isolation method can be utilized to determine pentazocine in pentazocine lactate injection. Pentazocine is eluted from the column with methanol 6 N HC1 (1 1). Sample absorbance is read at 278 nm and compared to a pentazocine standard at approximately 120-w.g/ mL (3). 

As nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate ALPE, the administration of NSAIDs should be avoided even after onset. When patients require analgesic agents, synthetic opioid agonist/antagonist analgesics (pentazocine hydrochloride or buprenorphine hydrochloride) should be administered. 

Coniine Hydrobromide 218 Pentazocine Hydrochloride 228-229d Ambutonium Bromide ... 

Guanethidine Monosulphate Mepacrine Hydrochloride Methaqualone Hydrochloride Morphine Sulphate Piperazine Adipate Sulfaquinoxaline Indoramin Hydrochloride Dexamethasone Triclocarban Racemorphan T ryptamine Hydrochloride Nefopam Hydrochloride Pentazocine Hydrochloride Protoveratrine B Morphine Bufylline... 

Pentasa mesalazine. pentazocine [ban,inn.jan,usan] (pentazocine hydrochloride [usan] pentazocine lactate [usan] NSC 107430 Fortagesic Fortral Talwin ) is one of the benzomorphan series and is a (mixed partial p and full k) OPIOID RECEPTOR AGONIST with OPIOID ANALGESIC activity. It is used orally or by injection to treat moderate to severe pain, pentazocine hydrochloride pentazocine, pentazocine lactate pentazocine, pentetrazol [ban, inn] (pentylenetetrazole pentamethylenetetrazole) has similar properties to doxapram as a CNS stimulant and respiratory stimulant. It was previously used intramuscularly to treat barbiturate and other CNS depressants in overdose, and orally for bronchial disorders. 

Tablets for oral use now contain pentazocine hydrochloride (equivalent to 50 mg of the base) and naloxone hydrochloride (equivalent to 0.5 mg of the base Talwin NX), which reduces the potential use of tablets as a source of injectable pentazocine. After oral ingestion, naloxone is destroyed rapidly by the liver however, if the material is dissolved and injected, the naloxone produces aversive effects in subjects dependent on opioids. An oral dose of about 50 mg pentazocine results in analgesia equivalent to that produced by 60 mg codeine oraUy.

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