Formic acid hydrazide

Chloro-1.3-dihydro-5-phenyl-2H-1,4-benzodiazeplne-2-thione Formic acid hydrazide... 

Formaldehyde diethyl acetal, d307 Formic acid hydrazide, f38 Formylamide, f33... 

Formic acid hydrazide reacts in an abnormal manner. It is 1,3,4-thiadiazolidine-2,5-dithione which is formed (2) (see also VII.5). 

Formyl hydrazine (formic acid hydrazide) [624-84-0] M 60.1, m 54 , 54-57 , pKest 2.5. RecrystalUse it from EtOH and dry it in vacuo. Store below 10 it may disproportionate on storage to 1,2-drforrrtyl hydrazine and hydrazine. It forms a blue [Cu(CH4N20)]S04 salt with CUSO4. Beilstein 2 H 93,2 HI 127,2IV 85.]... 

Phenoxaphosphine ring-containing poly (1,3,4-oxa-diazoles) were synthesized by cyclodehydration of poly-hydrazides obtained from (BCPO) and aliphatic and aromatic dihydrazines [152]. All these polymers are soluble in formic acid, w-cresol and concentrated H2SO4. The polyhydrazides yield transparent and flexible films when cast from DMSO solution under reduced pressure at 80-100°C. The polyhydrazides exhibit reduced viscosities of 0.24-0.40 dl/g in DMAC. Phenoxaphosphine ring-containing oxadiazole polymers showed little degradation below 400°C. 

On the other hand, refluxing 9 in formic acid for 5 h afforded the N-formyl derivative 11 in high yield. Acetylation of 9 by refluxing in acetic acid, afforded acetic acid N -(2-(7-hydroxy-2-oxo-2H-chromen-4-yl)-acetyl)-hydrazide 12 in good yield. Compound 13 was also obtained by refluxing 9 with 3-(2-bromoacetyl)-4-hydroxy-2H-chromen-2-one in ethanol. Reaction of compound 9 with phenyl isothiocyanate in ethanol at room temperature gave 4-phenyl-1 - (7-hydroxy-2-oxo-2 H-chromen-4-acetyl- )thiosemicarbazide 14. 

Acylaminobiguanides are cyclised by alkalis without difficulty, with loss of water, to 5-guanidino-l,2,4-triazoles. Their interaction with formic acid affords the expected guanamines in the majority of examples 391, 392) (see also Section VII, I). Contrary to a previous claim 91), isonicotinic acid hydrazide dihydrochloride and cyanoguanidine do not give the biguanide under neutral conditions, but form merely a molecular adduct of the reactants 416). 

Malic and citric acids have been adequately identified from molasses as their crystalline hydrazides.119 It is probable that at least the former is a normal juice constituent. Lactic acid was identified as its zinc salt in molasses119 it arises from bacterial action. Formic acid is present119 it probably has an origin, at least in part, in sugar decomposition. Acetic and propionic acids are components and their amounts serve as a rough index of the activity of the microorganisms introduced into the molasses. The microbial count of cane juice, molasses and related products has been determined (Table IV).190... 

Phenyl-1,3,4-thiadiazole (3, R = Ph) was first prepared by Ohta et al. by thioformylation of benzhydrazide with sodium dithio-formate, followed by dehydrating cyclization in sulfuric acid. In the same way the 2-benzyl and some aromatic analogs were obtained. Holmberg prepared 3 (R = Ph) by oxidation of l-methylene-2-thiobenzoylhydrazine (9) and of glyoxylic acid thiobenzhydrazone (10) with ferric chloride, and finally by reaction between thiobenz-hydrazide (11) and formic acid. 

Anthranilic acid hydrazides (104), prepared from lA and hydrazines,are used as precursors for quinazolines, benzotriazinones, and benzotriazepines. Cyclization of 104 with formic acid gives 3-amino-quinazolone (105) 3-aminoquinazolinedione (106) is obtained from urea and the unsubstituted hydrazide 104(R = = H), while ring closure... 

Thermal degradation of polyoxymethylene and polyacetals results in the formation of formaldehyde, which is furthermore catalyzed by oxidation of formaldehyde to formic acid. In addition to antioxidants and acid scavengers, formaldehyde scavengers are used in polyacetal formulations. Formaldehyde scavengers of choice are nitrogen compounds, for example, melamine derivatives such as benzoguanamine, urea derivatives such as allantoin, hydrazides, imides, and polyamide. 

Activation of Carboxylic Acids Synthesis of Acyl Imidazoles. iV,AA-Carbonyldiimidazole (1) converts carboxylic acids into the corresponding acylimidazoles (2) (eq 1). The method can be applied to a wide range of aliphatic, aromatic, and heterocyclic carboxylic acids, including some examples (such as formic acid and vitamin A acid) where acid chloride formation is difficult. The reactivity of (2) is similar to that of acid chlorides, but the former have the advantage that they are generally crystalline and easily handled. Isolation of (2) is sirr5>le, but often unnecessary further reaction with nucleophiles is usually performed in the same reaction vessel. Conversion of (2) into acid chlorides (via reaction with HCl), hydrazides, hydroxamic acids, and peroxy esters have all been described. Preparation of the more irr5)ortant carboxylic acid derivatives is described below. 

The poly(triazole) produced has a very high glass transition temperature of 260 C. It can be wet or dry spun from formic acid. The fibers still retain 30% of their original elongation at break even at 300 C. But to obtain poly(oxadia-zole) fibers, poly(phenylene hydrazide) is spun. Water is eliminated from their drawn or undrawn fibers to produce poly(oxadiazole) fibers. 

The poly[3,5-(4-phenyl-l,2,4-triazole)-1,4-phenylene] (I), with a Tq of 260 C, that is produced here can be dry- and wet-spun from formic acid solution. At 300°C the fibers still retain 30% of their original extension to break. The elimination of water to give polyoxadiazole can be carried out on drawn or undrawn poly(phenylene hydrazide) fibers. Here (II) is poly[3,5(4-oxa-1,2-diazole)-1,4-phenylene]. 

To a stirred mixture of phenyl hydrazine (1 mol) and urea (1 mol) in dimethyl benzene (500 mL), concentrated hydrochloric acid was added. The mixture was stirred at 135 °C for 2.5 h with a water separator to remove water. When the mixture was cooled to 90 °C, 85 % formic acid (2.5 mol) followed by concentrated sulfuric acid (0.25 mol) were added. The mixture was kept at 90 °C for 6 h and then the mixture was cooled. The solid was collected by filtration and washed by water, and dried at 100 °C in vacuo to give phenylhydrazide M6 as a white solid (mp 280-283 °C) in yield of 83 %. The hydrazide M6 (0.5 mol) was dissolved in 0.6 M NaOH solution and stirred for 1-2 h. The mixture was filtered and the solid product was dried at 100 °C in vacuo to give the sodium salt of l-phenyl-3-hydroxy-l,2,4-triazole M7 [19]. 

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