Formaldehyde diethyl acetal

Formaldehyde diethyl acetal, d307 Formic acid hydrazide, f38 Formylamide, f33... 

HYDROXYL GROUPS 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone. Formaldehyde diethyl acetal. 

Konishi, H. Nakamura. T. Ohata. K. Kobayashi, K. Morikawa. O. The acid-catalyzed condensation of 2-propylresorcinol with formaldehyde diethyl acetal. The formation and isomerization of calix[4]octol, calix[5]octol, and ca]ix[6]octoL Tetrahedron Lett. 1996, 37. 7383-7386. 

Formaldehyde cyclododecyl ethyl acetal. See Formaldehyde ethyl cyclododecyl acetal Formaldehyde cyclododecyl methyl acetal. See Formaldehyde methyl cyclododecyl acetal Formaldehyde diethyl acetal. See Diethoxymethane... 

Indeed, on Pd/SiO adsorbed formaldehyde was characterized with dimethyl- or diethylsulfate in the form of formaldehyde dimethyl or diethyl acetal, respectively. The highest concentration of formaldehyde (10 mol.(g of cat) )) was observed when only CO was added to the prereduced Pd catalyst (42). With an excess of hydrogen as well as on more active magnesium containing catalyst, only trace amounts of adsorbed formaldehyde were detected. Its low concentration on these catalytic surfaces may result from rapid conversion of adsorbed formaldehyde into methoxy moieties (Table I). 

The reaction of indolizines with aldehydes and ketones in the presence of acids yields coloured salts, two of which (43 and 44) are given here for illustration. The salts (45) and (46) have been obtained from the reaction of the pertinent indolizines with formaldehyde and glyoxal respectively. Polymethine dyes, some of which have found application in photography, have been prepared from indolizines and malondialdehyde derivatives or vinylogous dialdehydes (47) was prepared from 1,2-dimethylindolizine and /3-ethoxy-acrolein diethyl acetal (48). 

Fulminate can be prepared from acetaldehyde instead of from alcohol, and from substances which are convertible into acetaldehyde, such as paraldehyde, metaldehyde, dimethyl- and diethyl-acetal. Methyl alcohol, formaldehyde, propyl alcohol, butyralde-hyde, glycol, and glyoxal do not yield fulminate. ... 

Oxidation of compounds of the types thus far discussed proceeds readily at room temperature. Certain compounds which show no substantial reaction with periodic acid at room temperature can be oxidized at elevated temperature.22- 23 26 Thus, at 100° in aqueous solution the acetone mole exile is split to produce acetic acid and formaldehyde diethyl ketone yields propionic acid and probably ethanol lactic acid gives acetaldehyde and carbon dioxide acetaldehyde is oxidized to formic acid and methanol, which is converted into formaldehyde and pyruvic acid yields acetic acid and carbon dioxide. 

Whereas exhaustive chlorination of acetaldehyde dimethyl acetal (at not more than 60°) affords formaldehyde, 1-chloroethyl ethyl ether, trioxymethyl-ene, and HC1 as main products, exhaustive chlorination of the diethyl acetal (at 60-70°) gives a product that, on treatment with concentrated H2S04, affords chloral in good yield.629 The mixtures afforded by chlorination of acetals contain, inter alia, chloro ethers derived by reaction with the HC1 formed the chloro acetals are obtained by subsequent addition of ethoxide. 

A two-site PTC (1) prepared from acetophenone, formaldehyde, HCl, and triethylamine in three steps is effective in promoting dichlorocyclopropanation. It is of interest to note that 1,1,2-tribromocyclopropane undergoes decomposition to give the diethyl acetal of propargylaldehyde under PTC in the presence of an alcohol. ... 

Cyclic acetals of ketoses are prepared most commonly from acetone or benzaldehyde formaldehyde, acetaldehyde, butanone, and cyclohexanone have been used occasionally. These carbonyl reagents are frequently used directly, although such derivatives as 2,2-di-methoxy- or 2,2-diethoxy -propane (acetone dialkyl acetals), or l,l-dimethoxyethane (acetaldehyde diethyl acetal), are often employed in experiments in which intermediate acetals are of interest,or in which the presence of water in the reaction mixture adversely affects the yield of products. A polymeric form of an aldehyde is the reagent to be preferred whenever the monomer is volatile for example, acetaldehyde is often used in the form of a trimer, paraldehyde, and formaldehyde is employed as formalin solution, as paraformaldehyde, or as polyoxymethylene. An excess of the carbonyl reagent is generally used as the solvent, and the condensation is usually effected at room temperature. 

The Pictet-Spengler reaction has been combined with Ugi multi-component chemistry to construct a number of polycyclic indoles. Isonitrile derivatives prepared from tryptamine (or methyl tryptophanate), a carboxylic acid and formaldehyde condense with aminoacetaldehyde diethyl acetal. A few examples employed substituted aldehydes [352]. 

Aq.30%-H2O2 added with ice-cooling to a soln. of formaldehyde diethyl mercaptal in acetic acid, and stirred 2 hrs. at room temp. -> ethyl ethylthiomethyl sulfoxide. Y 83%. - Other oxidants did not give satisfactory results. F. e. s. K. Ogura and G. Tsudiihashi, Bull. Chem. Soc. Japan 45, 2203 (1972). 

Notable examples of general synthetic procedures in Volume 47 include the synthesis of aromatic aldehydes (from dichloro-methyl methyl ether), aliphatic aldehydes (from alkyl halides and trimethylamine oxide and by oxidation of alcohols using dimethyl sulfoxide, dicyclohexylcarbodiimide, and pyridinum trifluoro-acetate the latter method is particularly useful since the conditions are so mild), carbethoxycycloalkanones (from sodium hydride, diethyl carbonate, and the cycloalkanone), m-dialkylbenzenes (from the />-isomer by isomerization with hydrogen fluoride and boron trifluoride), and the deamination of amines (by conversion to the nitrosoamide and thermolysis to the ester). Other general methods are represented by the synthesis of 1 J-difluoroolefins (from sodium chlorodifluoroacetate, triphenyl phosphine, and an aldehyde or ketone), the nitration of aromatic rings (with ni-tronium tetrafluoroborate), the reductive methylation of aromatic nitro compounds (with formaldehyde and hydrogen), the synthesis of dialkyl ketones (from carboxylic acids and iron powder), and the preparation of 1-substituted cyclopropanols (from the condensation of a 1,3-dichloro-2-propanol derivative and ethyl-... 

Synthesis of isomeric chiral protected (63 )-6-amino-hexahydro-2,7-dioxopyrazolo[l,2- ]pyrazole-l-carboxylic acid 280 is shown in Scheme 36. Crude vinyl phosphonate 275, obtained by treatment of diethyl allyloxycarbonylmethyl-phosphonate with acetic anhydride and tetramethyl diaminomethane as a formaldehyde equivalent, was used in the Michael addition to chiral 4-(f-butoxycarbonylamino)pyrazolidin-3-one 272. The Michael addition is run in dichloro-methane followed by addition of f-butyl oxalyl chloride and 2 equiv of Huning s base in the same pot to provide 276 in 58% yield. The allyl ester is deprotected using palladium catalysis to give the corresponding acid 277, which is... 

Cyanogen chloride Cyclohexane Diethyl ether Dimethyl formaldehyde Dimethyl sulfate Dimethyl sulfide Epichlorohydrin Ethyl acetate Ethyl benzene Ethylene glycol Fluorine... 

Chloroethane, Chloroform, Diethyl phthalate. Ethyl acetate. Ethyl acrylate. Ethyl bromide. Ethyl ether. Ethyl formate. Formaldehyde, Methoxychlor, Nitromethane, Parathion, Phorate. Ouizalofop-ethvl Ethanolamine, see Ethylenimine, Morpholine Ethoxyacetaldehyde, see 2-Ethoxyethanol 2-Ethoxy-2-methylpropanal, see Ethyl tert-butvl ether Ethylacetamide, see Dimethylamine, Triethylamine Ethyl acetate, see Nitromethane, Tetrachloroethylene... 

Capello et al.16 applied LCA to 26 organic solvents (acetic acid, acetone, acetonitrile, butanol, butyl acetate, cyclohexane, cyclohexanone, diethyl ether, dioxane, dimethylformamide, ethanol, ethyl acetate, ethyl benzene, formaldehyde, formic acid, heptane, hexane, methyl ethyl ketone, methanol, methyl acetate, pentane, n- and isopropanol, tetrahydrofuran, toluene, and xylene). They applied the EHS Excel Tool36 to identify potential hazards resulting from the application of these substances. It was used to assess these compounds with respect to nine effect categories release potential, fire/explosion, reaction/decomposition, acute toxicity, irritation, chronic toxicity, persistency, air hazard, and water hazard. For each effect category, an index between zero and one was calculated, resulting in an overall score between zero and nine for each chemical. Figure 18.12 shows the life cycle model used by Capello et al.16... 

In a mixture of 1.32 g of sodium acetate, 0.8 ml of sodium acetate, 40 ml of water and 200 ml of ethanol were dissolved 10 g of the colorless froth obtained, and 1.0 g of palladium black was added to the above solution. Catalytic reduction was performed for 5 hours at room temperature under atmospheric pressure in a gentle hydrogen stream. 32 ml of 37% aqueous formaldehyde solution were poured into the reaction mixture and the catalytic reduction was continued for a further 7 hours. After completion of the reaction, the catalyst was filtered off and the filtrate was concentrated under reduced pressure approximately to a quarter volume. To the concentrate were added 100 ml of water, and the mixture was adjusted to about pH 10 with an aqueous sodium carbonate solution. The mixture was extracted thoroughly with chloroform and the extract was washed with water and dried. After evaporation of the solvent in vacuo, the residue was recrystallized from a mixture of chloroform and diethyl ether, giving 6 g of crystals. 

It is evident from Figure 1.3 that formaldehyde, dioxane, organic acids, acetonitrile and THF are not desirable solvents. THF and formaldehyde are significant outliers on this last graph because of their particularly poor performance under one of the assessment methods. Methanol, ethanol and methyl acetate are preferred solvents based on their EHS assessment. Heptane, hexane and diethyl ether are preferred based on LCA. However, it must be noted that the LCA was performed based on petrochemical production of the solvents and if the first group of solvents was bio-sourced, perhaps these three solvents... 

A diethyl ether cool flame, followed by a second-stage flame can be stabilized in a tube [74] or above a burner [75—77], and Agnew and Agnew [78] have used a quartz probe to remove samples from various positions in these flames. Numerous products were identified including not only carbon monoxide, carbon dioxide, water, various saturated and unsaturated hydrocarbons, acetaldehyde, formaldehyde, methanol, ethanol and acetic acid, but also ethyl formate, ethyl acetate, acetone, propionaldehyde and 2-methyl-l 3-dioxacyclopentane. The main features of the analytical results were... 

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