Follicular hyperkeratosis

Deficienqr of vitamin A results in night blindness (rod cells are responsible for vision in low light), metaplasia of the corneal epithelium, dry eyes, bronchitis, pneumonia, and follicular hyperkeratosis. 

The most obvious health effect in humans for exposure to CDDs is chloracne, a severe skin disease characterized by follicular hyperkeratosis (comedones) occurring with or without cysts and pustules.Unlike adolescent acne, chloracne may affect almost every follicle in an involved area, and it may be more disfiguring than adolescent acne. ... 

The dehciency disease associated with a lack of ascorbic acid is called scurvy. Early symptoms include malaise and follicular hyperkeratosis. Capillary fragility results in hemorrhages, particularly of the gums. Abnormal bone and tooth development can occur in growing children. The body s requirement for vitamin C increases during periods of stress, such as pregnancy and lactation. 

Deficiency symptoms Bitot s spots, xerosis, night blindness, keratomalacia, diarrhoea, follicular hyperkeratosis, papular eruptions, drying of epidermis, urinary calculi, degeneration of testis, impaired spermatogenesis, sterility, abortion, impairment of smell and taste. 

Signs and symptoms of mild vitamin A deficiency are easily overlooked. Skin lesions, such as follicular hyperkeratosis and infections, are among the earliest signs of deficiency, but the most... 

Low levels of LA are found in the sebum of acne sufferers,200 and levels appear inversely related to sebum secretion rate.201 It has been hypothesized that this local EFA deficiency may lead to the follicular hyperkeratosis and occlusion of acne, and that an increased supply of linoleate might possibly ameliorate the condition.202 In support of this, digital image analysis revealed that topical application of LA over a one month period reduced the size of microcomedones.203 Decreased levels of LA may also contribute to acne inflammation by failing to inhibit phagocytosis and ROS generation by neutrophils.204... 

Vitamin A deficiency is characterized by xerophthalmia, follicular hyperkeratosis (phrynoderma), and generalized xerosis.29 In hypervitaminosis A the skin becomes dry, rough, pruritic, and scaly and the lips become cracked. 

Pure vitamin A has an activity of. 1.5 million tU/g. Moder-ntc-to-ma.ssive doses of vitamin A have been u.sed in pregnancy. lactation, acne, termination of colds, removal of persistent follicular hyperkeratosis of the arms, persistent and abnormal warts, com.s, and callases, and. similar condition.s. Phosphatides or the tocopherols enhance the absorption of vitamin A. Vitamin A applied topically appears to reverse the impairment of wound healing by corticoid.s. 

A Supplement vitamin A deficiency states (malnutrition), impairment of absorption or transport Therapy nyctalopia, difficulties of adaptation to darkness, xerophthalmia, severe skin or mucosa damages, follicular hyperkeratosis, acne, inner ear deafness, tinnitus Retinyl palmitate, retinyl acetate Tablets, capsules, drops, emulsion, suspension, ointment, ampules 7,500-100,000 lU 420-700 pg 800-1,000 pg... 

Prolonged oil exposure produces a reactive follicular hyperkeratosis and results in sebum retention. This manifests clinically as multiple open comedones, inflammatory folliculitis and microcystic lesions caused by the oil itself. Lesions are distributed primarily over exposed areas, such as the dorsal hands and extensor forearms. Oil-soaked clothing may produce lesions on the thighs, lower abdomen and buttocks (Kokelj 1992). The face may be involved from wiping the brow with an oil-contaminated sleeve. Although the lesions are commonly referred to as oil boils, they usually do not develop from bacteria present in the oils (Taylor 1986). The inflammatory lesions are more prominent than in chloracne and may mimic conglobate cystic acne. 

PCBs) folliculitis and xerosis (TCAB, TCAOB) and actinic elastosis (TCDD). Erythema and edema of the exposed face and extremities associated with trichlorophenol production was also seen in the Seveso cases. These pre-chloracne lesions were also accompanied by vesiculobullous and necrotic lesions on finger tips and palms, and papulonodular lesions, all of which resolved within a few weeks. Hyperkeratotic, infiltrative erythematous granuloma annulare or erythema elevatum diutinum-like lesions were also seen in association with chloracne 2 months after the explosion. Axillary involvement and follicular hyperkeratosis are linked with inhalation or ingestion of chloracnegens (Taylor 1979 Tindall 1985). 

It seems probable that xerosis of the skin with hyperkeratinization, so-called toad skin or phrynoderma, also represents vitamin A deficiency in man. The relationship of vitamin A to mild skin changes such as localized areas of keratinization of the hair follicles, follicular hyperkeratosis, is less well documented. Vitamin A deficiency may be responsible for the lesions in some instances but certainly not in all. Unequivocal follicular keratotic changes have not been produced experimentally in man. ... 

Aroclor 1260 in an isopropanol vehicle to the shaved back skin of female New Zealand rabbits 5 days/week for 28 or 38 days at estimated doses of 42-44 mg/kg/day (Vos and Beems 1971 Vos and Notenboom-Ram 1972). Effects included thickening of the skin and acneform lesions resulting from hyperplasia and hyperkeratosis of the epidermal and follicular epithelium. 

Clinical findings — There was gross hyperkeratosis, with blisters in areas on hands and feet. There was onychia of hands and feet, multiple follicular keratoses, acne, comedones, cystic lesions and lipomata on trunk and limbs. Hyperkeratotic plaques on tongue. 

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