New Zealand rabbits

Male New Zealand rabbits displayed nephrosis of the convoluted tubules and nephrocalcinosis when given doses of 320 and 1,000 mg/kg/day hexachloroethane in methyl cellulose solution for 12 days (Weeks et al. 1979). Kidney weights were increased significantly for the 1,000 mg/kg/day dose. There were no observed effects on the kidney with a dose of 100 mg/kg/day. 

New Zealand rabbits exposed to 3,000 ppm -hexane for 8 hours a day, 5 days a week for 24 weeks, showed no signs of peripheral neurotoxicity (hindlimb weakness, foot dragging) (Lungarella et al. 1984). 

Preparation of Rabbit Serum and Antiserum. Four white New Zealand rabbits (2-3 kg) were first bled to obtain normal serum (NS), then injected subcutaneously with a total of 2.5 mg of either f-1, f-3, f-4, or f-5 in complete Freund s adjuvant. 

Antihypercholesterolemic effect. Polico-sanol, administered orally to normocholes-terolemic New Zealand rabbits at doses of 5-200 mg/kg for 4 weeks, significantly reduced total cholesterol and low-density lipoprotein cholesterol (LDL-C) serum levels in a dose-dependent manner. Serum triglyceride (TC) levels of the treated and control animals were significantly different, but the reduction observed was not dose-dependent. High-density lipoprotein cholesterol (HDL-C) levels remained unchanged. The results indicated that the reduction in total cholesterol values induced by policosanol was mainly mediated through a decrease in LDL-C levels . Policosanol was administered to patients who were obese (body mass... 

Nasal discharge was observed in New Zealand rabbits of both sexes following dermal exposure for 24 hours to 2,020 mg/kg of the diazinon MG-8 formulation (Kuhn 1989b). The purity of this formulation was not reported but was probably about 87% based on similar reports for the MG-8 formulation reported by the manufacturer, Ciba-Geigy. 

Body Weight Effects. Body weight was unaffected in New Zealand rabbits dermally exposed to up to 2,020 mg/kg for 24 hours to the diazinon MG-8 formulation (purity not reported but probably about 87%) and observed for a further 14 days (Kuhn 1989b). 

Sprague-Dawley rats were exposed by inhalation to 80,316 or 630 mg/m vinylidene for 7 h per day on days 6-15 of pregnancy. New Zealand rabbits were exposed to 316 or 630 ing/m on days 6-18 of pregnancy (Murray et al., 1979). Toxicity was noted in the dams at 316 mg/m in rats and 630 mg/m in rabbits. Resorptions in dams and skeletal variations in pups were increased in rabbits at 630 mg/m . Skeletal variations were also noted in rats exposed to 316 mg/m and 630 mg/m. ... 

Prior to true subsurface bone spectroscopy, Penel and coworkers obtained bone Raman spectra using a titanium chamber with a fused silica window placed in the calvaria of New Zealand rabbits [2]. With this apparatus they were able to study both bone tissue and implanted hydroxyapatite and P-tricalcium phosphate over a 8-month period. In addition to bone spectra, hemoglobin spectra were obtained close to blood vessels. 

New Zealand rabbits are the preferred laboratory strain used for polyclonal antiserum production (see Note 2). 

New Zealand rabbits are normally used for serum production they are easily handled and adapt well to individual cages or group floor pens. This strain has half-lop ears, which make blood collection from marginal veins a fairly straightforward procedure. 

Murray et al. (1979) reported an increase in the occurrence of omphalocele in New Zealand rabbits (200 mg/kg/day) p.c. days 6 to 18. Robens (1969) had observed no embryotoxic or teratogenic effects on New Zealand rabbits in a comparable experiment. 

Skin damage has been observed in female TF, Carworth mice, New Zealand rabbits, and Large White pigs following the application of 10% aluminum chloride (0.005-0.1 g Al) or aluminum nitrate (0.006-0.013 g Al) for 5 days but not from aluminum sulfate, hydroxide, acetate, or chlorhydrate (Lansdown 1973). The damage consisted of hyperplasia, microabscess formation, dermal inflammatory cell infiltration, and occasional ulceration. These results suggest that the development of adverse dermal effects from exposure to aluminum depends upon its chemical form. 

Allison BA, Crespo MT, Jain AK, et al. Delivery of benzopor-phyrin derivative, a photosensitizer, into atherosclerotic plaque of Watanabe heritable hyperlipidemic rabbits and balloon-injured New Zealand Rabbits. Photochem Photobiol 1997 65(5) 877-883. 

Single-dose dermal LD50 values in New Zealand rabbits exposed to chromium(VI) as sodium chromate, sodium dichromate, potassium dichromate, and ammonium dichromate were determined by Gad et al. (1986). LD50 values ranged from 361 to 553 mg chromium(VI)/kg for females and from 336 to 763 mg chromium(VI)/kg for males. Signs of toxicity included dermal necrosis, eschar formation, dermal edema and erythema, and diarrhea and hypoactivity. The dermal LD50 value for chromium trioxide was 30 mg chromium(VI)/kg for combined sexes (American Chrome and Chemical 1989). The LD50 values are recorded in Table 2-3. 

Diarrhea was reported in New Zealand rabbits exposed to lethal concentrations of chromium(VI) compounds (Gad et al. 1986). 

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