Fibrous tumour

A solitary fibrous tumour was first described in pleural tissue by P. Klemperer et al. in 1931. Meanwhile, this rare entity has been reported in various organs, with the liver being affected in 26 cases. The tumour shows cellular areas (consisting of bundles of spindle cells arrayed haphazardly or in a storiform pattern) and relatively acellular areas (containing abundant collagen bundles). There is evidence of cellular atypia, mitotic activity and ectatic vessels. This tumour possesses malignant potential with the ability to metastazise. (134)... 

Neeff, H., Obermaier, R., Technaulhling, K., Werner, M., Kurtz, C., Imdahl, A., Hopf, U.T. Sohtary fibrous tumour of the liver case report and review of the hterature. Langenbecks Arch. Surg. 2004 389 293-298... 

Al-Izzi M, Thurlow NP, Gorrin B. Pleural mesothelioma of connective tissue type, localized fibrous tumour of the pleura and reactive submesothelial hyperplasia An immunohistochemical comparison. J Pathol. 1989 157 41-44. 

Fukunaga M, Naganuma H, Ushigome S, et al. Malignant solitary fibrous tumour of the peritoneum. Histopathology. 1996 28 463-466. 

Damiani S, Miettinen M, Peterse JL, et al. Solitary fibrous tumour (myofibroblastoma) of the breast. Virchows Arch. 1994 425 89-92. 

Brown, G.M., Li, X.Y. and Donaldson, K. (1991a). Secretion of interleukin 1 and tumour necrosis fector by alveolar macrophages following exposure to particulate and fibrous dusts. In Mechanisms in Fibre Carcint nesis (eds. R.C. Brown, J.A. Hoskins and N.F. Johnson) pp. 499-504. Plenum, New York. 

This outline is not exhaustive. For example there is an increasing awareness of the role played by infection with the human immunodeficiency virus while infiltration of the marrow with fibrous tissue or tumour cells will decrease production. In much the same way massive splenomegaly, so common in tropical Africa, sequesters significant volumes of red cells while malarial infection results in their accelerated breakdown. In some cases defects are multifactorial as in chronic lymphocytic leukaemia where infiltration decreases production, splenomegaly traps large amounts of blood while immune mechanisms lead to shortened survival or haemolysis. 

Focal nodular hyperplasia (see chapter 36.4.2) — as a benign hepatocellular tumour - is mostly hypoechoic. Occasionally, it can be differentiated as a protruding contour or a pediculate liver tumour. Compression of the surrounding liver tissue may be the cause of a visible capsule , which actually has no anatomical structure of its own. At a size of > 3 cm, fibrous septa and arteries... 

Fibrosarcoma is a mesenchymal tumour originating from fibroblasts it can therefore occur ubiquitously in the whole body. (12) It was first described by R.H. Jaefe in 1924. About 35 cases have been reported so far. This type of tumour has a firm consistency and contains cystic structures with focal necroses and haemorrhages. It possesses a fibrous pseudocapsule and consists of fascicu-larly arranged, spindle-like or fusiform tumour cells embedded in parallel collagen fibres. The non-epithelial stroma marker vimentin is overexpressed. These cells may exhibit marked polymorphism. Fibrosarcoma mainly occurs in men of advanced age. Therapy consists of tumour resection and adjuvant chemotherapy. (280,281)... 

Many drugs cause diuresis by influencing the secretory and resorptive properties of the kidneys which were discussed in Section 3.1. Several drugs are known which act directly on the haematopoietic system (e.g. phenindione, warfarin, sodium calcium edetate, amethopterin), on fibrous tissues (e.g. salicylates, prednisolone, cortisone), and on tumours. 

Schwerck W, Braun B, Dombrowsky H (1979) Real time ultrasound examination in the diagnosis of gastrointestinal tumours. J Clin Ultrasound 7 425-431 Sheafor DH, Paulson EK, Simmons CM et al (1998) Abdominal percutaneous interventional procedures comparison of CT and US guidance. Radiology 207 705-710 Shidham VB, Weiss JP, Quinn TJ et al (1998) Fine needle aspiration cytology of gastric solitary fibrous tumor. A case report. Acta Cytol 42 1159-1166 Smith EH (1984) The hazards of fine-needle aspiration biopsy. 

Angiographically, peripheral CCA is predominantly hypovascular, with thin dysplastic vessels corresponding to neovascularity and fibrous transformation of the tumour (Soyer et al. 1995a). Intrahepatic CCA are purely hypervascular in 30% of cases, but shows no arteriovenous fistulas, as seen commonly in... 

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