Inflammation and angiogenesis

Kellar RS, Kleinert LB, Williams SK. Characterization of angiogenesis and inflammation surrounding ePTFE implanted on the epicardium. Journal of Biomedical Materials Research 2002, 61, 226-233. 

Bonnet CS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology... 

Folkman, J. and Brem, H. (1992). Angiogenesis and inflammation. In Inflammation Basic Principles and Clinical Correlates (eds. J.l. Gallin, I.M. Goldstein and R. Snyderman), pp. 821-839. Raven Press, New York. 

Benelli R, Morini M, Carrozzino F, Ferrari N, Minghelli S, Santi L, Cassatella M, Noonan DM, Albini A Neutrophils as a key cellular target for angiostatin Implications for regulation of angiogenesis and inflammation. FASEB J 2002 16 267-269. 

Zachman, A.L., Wang, X., Tucker-Schwartz, J.M., Fitzpatrick, S.T., Lee, S.H., Guelcher, S.A., Skala, M.C., Sung, H.-J. Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels. Biomaterials 35, 9635-9648 (2014)... 

Jackson JR, Seed MP, Kircher CH, Willoughby DA, Winkler JD. The codependence of angiogenesis and chronic inflammation. FASEB J 1997 ll(6) 457-465. 

Dona, M. et al., Neutrophil restraint by green tea Inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis, J Immunol, 170, 4335, 2003. 

Mechanism of Action-. A selective vascular endothelial growth factor (VEGF) antagonize that selectively binds and activates receptors located on the surface of vascular endothelial cells. Therapeutic Effect Blocks angiogenesis and vascular permeability and inflammation which contribute to the progression of the neovascular (wet) form of age-related macular degeneration (AMD). 

In addition to the treatment of pain and inflammation, COX-2 inhibitors might be of benefit in other indications. Expression of COX-2 in colon cancer, intestinal adenomas, and other cancer cells as well as clinical studies with COX-2 inhibitors, suggest the use of COX-2 inhibitors in cancer (Masferrer et al., 1999). Expression of COX-2 in angiogenesis follows the same route since angiogenesis is important for blood supply and hence the growth of many tumors. 

Fibrinogen is a fibrous protein that was first classified with keratin, myosin, and epidermin based on its 5.1 A repeat in wide-angle X-ray diffraction patterns (Bailey et al., 1943), which was later discovered to be associated with the Q-helical coiled-coil structure. It is a glycoprotein normally present in human blood plasma at a concentration of about 2.5 g/L and is essential for hemostasis, wound healing, inflammation, angiogenesis, and other biological functions. It is a soluble macromolecule, but forms a clot or insoluble gel on conversion to fibrin by the action of the... 

The influence of NO in thrombogenesis, bacterial infection, angiogenesis, and the immune response suggest that its active release into the tissue surrounding a sensor may minimize the FBR. Sensor coatings that release NO could reduce the occurrence and severity of bacterial infection, minimize inflammation and collagen capsule formation, and promote the formation of new blood vessels, all of which would create a more favorable implant environment. Since NO is reactive (i.e., has a short half-life), the effects of NO would remain localized to the area from which it is released. 

G. Majno, Chronic inflammation. Links with angiogenesis and wound healing, Am. J. Pathol. 757 1035-1039 (1998). 

As the number of chemokines and receptors continue to expand so too does the list of ascribed biological functions. Beyond their characterized roles in leukocyte trafficking and inflammation, chemokines have been shown to effect angiogenesis (24-26), hematopoiesis (27-29), T-cell differentiation (30), apoptosis (31), and viral infection (32,33), although the biological significance of these effects as well as the mechanism of action remain to be determined in many cases. Furthermore, chemokine receptor expression has been reported on nonlymphoid cell types in brain and vasculature (34,35). Antibodies will no doubt prove to be useful in determining the function of these receptors in other systems. 

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