Federal Insecticide, Fungicide, and Rodenticide Act FIFRA

Under Section 3(c)(2) of FIFRA, the U.S. EPA is granted broad authority to require scientific testing and submission of the resulting data to the U.S. EPA by 

Once a product is approved for registration, the registrant is required, under Section 6(a)(2), to inform the U.S. EPA if the registrant obtains ... additional factual information regarding unreasonable adverse effects on the environment of 

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The tria2ine family of herbicides appeared in and after 1955, and the bipyridiniums in 1960. In 1967, two new chemical herbicides (1) were registered under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). The number of new registrations swelled to 11 in 1975 and subsequendy dropped to three in 1990 and two in 1991. 

Another section of the EPA, the Office of Prevention, Pesticides, and Toxic Substances (OPPT), has recently updated and harmonized its testing guidelines for evaluating the developmental and reproductive effects of pesticides and industrial chemicals to include an assessment of endocrine disrupting properties. These guidelines will be used in future testing of pesticides under both the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA). 

Federal Register, Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), 7 U.S. Code s/s 135 et seq. 1972, U.S. Government, Public Laws, 2009. Available at http //www.access.gpo.gov/uscode/title7/ chapter6. html... 

Analytical chemistry is a critical component of worker safety, re-entry, and other related studies intended to assess the risk to humans during and subsequent to pesticide applications. The analytical aspect takes on added significance when such studies are intended for submission to the U.S. Environmental Protection Agency and/or other regulatory authorities and are thus required to be conducted according to the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) Good Laboratory Practice (GLP) Standards, or their equivalent. This presentation will address test, control, and reference substance characterization, use-dilution (tank mix) verification, and specimen (exposure matrix sample) analyses from the perspective of GLP Standards requirements. 

In the five and one-half years of ensuing Congressional activity, many additional aspects were considered and some were included in the Act as finally enacted. Possibly the most controversial had to do with the treatment of new substances. Were these to be treated by registration, as is the case in the Federal Insecticide Fungicide and Rodenticide Act (FIFRA), or were they to be subject to a less onerous notification procedure This would begin the attempt to assess their risks more in balance with the growth in commercial volume of the substance, and hence with its capacity to pay the costs for the frequently costly testing required. Without such a balance, the... 

Under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), a 0 ppm food tolerance restriction is in place for endrin (EPA 1977b). 

In US, AF products need a registration both at federal and at state level. Registration/regulation of AF paints is governed by the Federal Insecticide, Fungicide, and Rodenticide Act FIFRA (US, 2004) and administered by US Environmental Protection Agency. Extensive data packages need to be submitted by the biocide producers and the paint manufacturers. The decision for approval of products is based upon a risk benefit balance evaluation process. 

In 1974, federally recommended procedures were published under authority of the 1972 amendments of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) that addressed pesticide disposal (2). These recommendations identified an incinerator operating at 1000°C (1832°F) with 2-s retention time in the combustion zone as acceptable for destruction of organic pesticides. Other incinerators, such as those for municipal solid waste capable of effecting complete pesticide destruction, are also acceptable. During this same time frame, i.e., from the early 1970s to date, a number of research and demonstration studies have been conducted involving pesticide incineration. Most of these concern either the identification of incinerator... 

Pesticide. . any substance or mixture of substances intended for preventing, destroying, repelling or mitigating any insects, rodents, nematodes, fungi, or weeds or any other form of life declared to be pests.. . . and any substance or mixture of substances intended for use as a plant regulator, defoliant or desiccant." Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA - 1947) DDT... 

Pesticide regulation makes use of measurements of specific fate and effects properties, as specified in laws such as the US Federal Insecticides Fungicides and Rodenticides Act (FIFRA). Studies are conducted according to relatively standardized designs. Particularly in this type of situation, it seems reasonable to develop default distributions for particular variables, as measured in particular, standardized studies. Default assumptions may relate to default distribution types, or default distribution parameters such as a coefficient of variation, skewness, or knrtosis. Default distributions may be evaluated in comparative studies that draw from multiple literature sources. Databases of pesticide fate and effects properties, such as those maintained by the USEPA Office of Pesticide Programs, may be useful for such comparative analyses. 

Environmental Protection Agency. Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) Good laboratory practice standards, proposed rule. Fed Reg 52 48920-48933, 1987 Environmental Protection Agency. Toxic Substances Control. Act (TSCA) Good laboratory practice standards, proposed rule. Fed Reg 52 489933-48946, 1987. 

The two main federal agencies involved in the protection of human health and the environment are the Environmental Protection Agency (EPA) and the Occupational Safety and Health Administration (OSHA). EPA s principal concern is the protection of the environment, in most cases, the area outside of an industrial facility. There are 10 regional offices that carry out the regulatory functions of the agency (Table 1). Primary laws covered by EPA are the Clean Air Act Amendments (CAAA), the Clean Water Act (CWA), Resource Conservation and Recovery Act (RCRA), Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), Toxic Substances Control Act (TSCA), and Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). 

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