Identification factors

General Description Locations Critical Factors Identification Elimination Cautions Related Problems Case Histories... 

Moncada, S., Radomski, M.W. and Palmer, R.M. (1988). Endothelium-derived relaxing factor identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem. Pharmacol. 37, 2495-2501. 

Signs and symptoms Predisposing factors Identification of the pathogen Collection of infected material Stains Serologies... 

Causal factor identification tools are relatively easy to learn and easy to apply to simple incidents. For more complex incidents with complicated timelines, one or more causal factors can be overlooked, ultimately leading to missed root causes. Another disadvantage is that an inexperienced investigator could potentially assume that suppositions are causal factors, when in reality the supposed event or condition did not occur. 

The process of evidence gathering, timeline development, scenario determination, and causal factor identification is somewhat iterative, and therefore some of the tools and quality tests previously described may assist in causal factor identification. More specifically, barrier analysis and change analysis, together with a completeness test, can ensure that all valid causal factors are identified. 

First, it is necessary to identify the multiple causal factors of the incident. The procedures in Causal Factor Identification may be used to identify tbe causal factors from a timeline or sequence diagram (including a causal factor chart). 

Almost three-quarters of the known proteins have no known cellular function but as we have learned in the past, nature seldom has true junk in its biological pile of macromolecules. In addition to identifying specific targets and target molecules, other discoveries are important such as new enzymes, signaling molecules, pathways, and finally mechanistic behaviors and factors. Identification of such factors will allow better drug discovery and activity downstream. 

Lasley MV. 1999. Allergic disease prevention and risk factor identification. Immunol. All. Clin North Am. 19 149-159. 

As our knowledge of the genome increases, so has it become clear that many conditions involve both multiple genes and environmental factors. Identification of individuals whose lifestyle or genetic makeup puts them at risk for particular diseases, raises ethical and social problems which are unresolved and have brought molecular and cell biology firmly into the social arena (see Epstein, 1997). 

The ultimate mechanism for benzene-induced suppression of cellular growth and the development of leukemia is not known at this time it could be one of the mechanisms discussed above (see also Section 2.4.2) but most likely the mechanism involves a combination of factors. Identification of the mechanism would be facilitated by clear identification of the specific target cell and intracellular target of benzene and its metabolites (Andrews and Snyder 1986). 

Anderegg, R.J., Betz, R., Carr, S.A., Crabb, J.W., and Duntze, W. (1988). Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-famesyl cysteine as a structural component. J Biol Chem 263 18236-18240. 

Risk-factor identification and modification are important for individual patients with known or suspected IHD and as a population-based policy to reduce the impact of this disease. 

Kawamoto, T., Sato, J. D., Jonathan, A. L., Polikoff,J., Sato, G.H., Mendelsohn, J. (1983). Growth stimulation of A432 cells by epidermal growth factor Identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal anti-bidy. Proc. Nat. Acad Sci., 80, 1337—1341. 

Setting the above knowledge and proposals together leads to integrated incident investigation procedure which is stUl based on the timeline development, causal factor identification and causal factor chart development, but which allows the determination of different Incident Cause Level for each of multiple causes. If the Incident Cause Level of specific cause is outside the internal safety management, the apph-cation of non-hnear analysis method is recommended. 

Causal Factors Identification of Factors Possible Corrective Actions... 

Promote root causal factor identification, analysis and resolution systems. 

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