Genes multiple

Multidmg Resistance Multidrug Resistance Gene Multiple Sclerosis... 

Hoffmeyer, S., Burk, O., von Richter, O., Arnold, H. P., Brockmoller, J., Johne, A., Cascorbi, I., Gerlo, T., Roots, I., Eichelbaum, M., Brinkmann, U., Functional polymorphism of the human multidrug resistance gene multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo, Proc. Natl. Acad. Sci. USA 2000, 97, 3473-3478. 

Hoffmeyer, S., et al., "Functional Polymorphisms of the Human Multidrug-Resistance Gene Multiple Sequence Variations and Correlation of One Allele with P-Glycoprotein Expression and Activity In Vivo," Proc. Natl. Acad. Sci. U.S.A., 97, 3473-3478 (2000). 

Hoffmeyer, S., Burk, O., von Richter, O., et al. (2000) Functional polymorphisms of the human multidrug-resistance gene multiple sequence variations and correlation of one allele... 

Transcription of genes Multiple genes arranged as operons in a single transformation event Each gene expressed individually... 

Larsson Forsell, P.K.A., B.P. Kennedy, and H.E. Claesson. 1999. The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene. Eur J Biochem 262 575. 

Rowatt, A.J., J.J. DePowell and W.H. Powell. ARNT gene multiplicity in amphibians characterization of ARNT2 from the frog Xenopus laevis. J. Exp. Zool. Part B. Mol. Dev. Evol. 300 48-57, 2004. 

Once these multiple-gene, multiple time point data have been collected, it will be necessary to organize them into an intelligible form. This can be accomplished with the right computational tools. Some relatively simple mathematical methods already in use in other fields can be adapted for the analysis of gene expression data. Two such methods discussed here include clustering [8, 9, 10], and Shannon entropy [11, 12]. 

Kwan, C.T., Tsang, S.L., Krumlauf, R., Sham, M.H. 2001. Regulatory analysis of the mouse Hoxb3 gene multiple elements work in concert to direct temporal and spatial patterns of expression. Dev. Biol. 232, 176-190. 

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