2 - ethylamine

Uses Ethylamine is a colorless, inflammable gas. A variety of manufacturing industries have been associated with this compound (e.g., dyestuff industry, pharmaceuticals, rubber latex stabilizers, oil refining). 

Toxicity Ethylamine causes severe irritancy to exposed skin, eyes, and mucous membranes. Direct contact with the skin of experimental animals resulted in skin bums, scarring, and necrosis.37-39 The chemical also caused adverse effects and degenerative changes in heart, liver, lung, kidney, and associated injury to the endocrine system of animals.40 

Uses Diethylamine is a colorless, inflammable, strongly alkaline, fishy-smelling liquid. It has several applications in industries such as organic synthesis of resins, 

In resin chemistry stabilizer for rubber latex intermediate for dyesmffs, pharmaceuticals in oil refining 

Toxieology. Ethylamine is an irritant of the eyes, mucous membranes, and skin. 

Eye irritation and corneal edema in humans have been reported from industrial 

Exposure of rats to 8000 ppm for 4 hours was fatal to two of six animals within 14 days. Rabbits survived exposures to 50 ppm daily for 6 weeks but showed pulmonary irritation and some myocardial degeneration corneal damage was observed 2 weeks after exposure. In the rabbit eye, one drop of a 70% solution of ethylamine caused immediate, severe irritation. A 70% solution dropped on the skin of guinea pigs caused prompt skin burns leading to necrosis when held in contact with guinea pig skin for 24 hours, there was severe skin irritation with extensive necrosis and deep scarring.  

The 2003 ACGIH threshold limit valuetime-weighted average (TLV-TWA) for ethylamine is 5 ppm (9.2 mg/m ) with a short-term excursion limit of 15ppm (27.6mg/m ) and a notation for skin absorption. 

250 ppm produced damage to respiratory mucosa of the nasal turbinates. Exposure to 750 ppm produced severe body weight losses, liver damage, and nasal degenerative changes. 

Any adverse health effects in humans due to methylamine, other than its irritant action, is unknown. 

Flammable gas the aqueous solutions are also flammable, flash point of a 30% solution 1.1 °C (34°F) the gas (vapor) is heavier than air (1.1 times that of air) and can travel a considerable distance to a source of ignition and flashback autoignition temperature 430°C (806°F) fire-extinguishing procedure shut off the flow of gas in case its aqueous solution catches fire, use a water spray, alcohol foam, dry chemical, or CO2 use a water spray to keep fire-exposed containers cool. 

Methylamine forms explosive mixtures with air the LEL and UEL values are 4.9% and 20.7% by volume in air, respectively. Methylamine reacts explosively with mercury. Violent reactions may occur when mixed with nitrosyl perchlorate or maleic anhydride. 

Methylamine is stored in a cool, well-ventilated noncombustible area separated from possible sources of ignition and oxidizing substances and mercury. Its solutions are stored in a flammable liquid storage room or cabinet. The gas is shipped in steel cylinders or tank cars the liquid is shipped in steel drums or tank cars. 

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Reductions in liquid ammonia run at atmospheric pressure at a temperature of —33°. If higher temperatures are necessary for the reduction, other solvents of alkali metals are used methylamine (b.p. — 6.3°), ethylamine (b.p. 16.6°), and ethylenediamine (b.p. 116-117°). 

Scheme 87 illustrates two potentially useful routes to the pyrazolo[3,4-rf]pyrimidine system. In (290) the usual higher reactivity of the halogen at C(4) is seen (see Section 4.05.3.3). Ethylamine monosubstitutes at room temperature, but disubstitution requires a temperature of 100 °C (75S645). Cyanoguanidine converts the aminopyrazole (263) into the pyrazolotriazine (291) on heating at 160 C (57G597). 

The conformational restrictions imposed on the indole-3-ethylamine moiety permitted retention of affinity for the 5-HT receptor but it diminished affinity for the 5-HT receptor by a factor of 1000. In two functional assays, (29) exhibited potency equal to or marginally greater than that of serotonin. Com-... 

Tryptamin indolyl-(3)-ethylamine, a biogenic amine, 160.2, produced by decarboxylation of tryptophan. T. stimulates contraction of the smooth muscle of blood vessels, uterus and central nervous system. It is found in both plants and animals, and as a bacterial degradation product of tryptophan. 

Na-acetate added to a soln. of oxindole-3-ethylamine hydrochloride in water-ethanol, warmed on a steam bath, an ale. soln. of 3,4-dimethoxyphenylacetalde-hyde added during 10 min., and refluxed 48 hrs. on the steam bath -> 3,4-di-methoxy 2-component base (Y 92%), perchlorate salt of which dissolved in hot water, excess 37%-formaldehyde added, and heated 1 hr. on a steam bath -> N-condensed heterocyclic (Y 91.6% as the hydrochloride).— The relative stereochemistry of the intermediate 2-component base is identical with that of strychnine, and the skeleton of the formaldehyde condensation product is similar to that of the Mitragyna alkaloids. Also 2,3-dimethoxy 2-component base s. J. B. Hendrickson and R. A. Silva, Am. Soc. 84, 643 (1962). 

Suggestions have been made that amphetamine, rather than inhibiting uptake of dopamine, actually releases it from nerve endings of the nigro-striatal system [192, 526], 4-Methoxyphenylethylamine, in doses of 50 mg/kg (i.p.), produces tremors and hypokinesia in mice [8, 527] which are reversed by a number of indole-3-ethylamines (44-48) with ED50 values less than 10 mg/kg [528] trihexyphenidyl and scopolamine were not effective in this respect. 

C4H23B8N2, 3 Ethylamine-5,6-/n ethyl-amino-octaborane(12), 28, 581 CftH2AB,oS2f Bis(dimethylsulfide) - dodecahydrodecaborane, 27, 772 C8H25B11CSN, Caesium tetramethylammonium tridecahydroundecaborate, 32B, 296... 

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