Ethylamine.hydrochloride

Ethylamine hydrochloride [557-66-4] M 81.5, m 109-110 . Crystd from absolute EtOH or MeOH/CHCl3. 

Common Name N-demethylorphenadrine hydrochloride N-methyl-2[o -(2-tolybenzyl)oxy]-ethylamine hydrochloride... 

HPentafluorophenyOadamantane, 59, 130 (Pentafluorophenyl)benzene, 59, 127 Pentafluorophenylcopper, 59, 124 Pentfluorophenylcopper complexes, 59, 127 PENTAFLUOROPHENYLCOPPER TETRAMER, 59,122 2-(Pentafluorophenyl)ethylamine hydrochloride, 57, 82... 

The reactions of 2-(3,4-dimethoxyphenyl)ethylamine hydrochlorides with the sodium derivative of diethoxycarbonylglutaconate (8, R = H) in refluxing ethanol afforded the corresponding aminomethylenemalonates (357) in 84-885 yields (56JOC336). 

The direct synthesis of the fused ring compound (55) from the reaction of phosphorus trichloride with ethylamine hydrochloride has already been described (Scheme 16). Its N-methyl analogue (67) can be obtained from the reaction of (MeNPX)3 (X = Cl or Br) with heptamethyldisilazane (Scheme 19). The identification of the structures of these fused-ring compounds, which are structurally related to the bicyclo(3.3.1)nonane carbocycles, pose difficult problems. An example of their... 

DC030 Rhodes, B. B., and C. V. Hall. Effects of CPTA 2-(4-chlorophenyltio)-tri-ethylamine hydrochloride, temperature, and genotype on carotene synthesis in carrot leaves. Hortscience 1975 10 22. 

A, A -Dimethyl-2-(a-phenyl-t -tolyloxy)ethylamine hydrochloride see phenyltoloxamine hydrochloride. 

A-Methyl ethylamine hydrochloride [624-60-2] M 95.6, m 126-130 . Crystd from absolute EtOH or ethyl ether. 

This reaction is general for the preparation of alkyl isothiocyanates in good yields thus, according to the submitters, ethyl isothiocyanate is obtained in yields of 60-70 per cent from ethylamine hydrochloride. 

SYNTHESIS A stirred solution of 9.0 g 1 -(3,4-methylenedioxypheny l)-2-butanone (see the recipe for J for its preparation) in 150 mL MeOH was treated with 9.0 g ethylamine hydrochloride, 4.0 g anhydrous NaOAc, and 3.0 g sodium cyano-borohydride. The pH was maintained between 6 and 7 by the periodic addition of HC1. After the base formation had stabilized, there was added an additional 9.0 g ethylamine hydrochloride, 9.0 g NaOAc and 2.0 g sodium cyanoborohydride. With continuous stirring, there was HC1 added over the course of 1 h until the final pH was approximately 2. The reaction mixture was poured into 700 mL dilute NaOH, and extracted with 3x75 mL CH2C1,. These extracts were pooled, and back-extracted with dilute H2S04. This was washed with 2x50 mL CH,CI2, then made basic with dilute NaOH and extracted with 2x75 mL CH2Clr Removal of the solvent... 

EtOAc mixture to provide 0.84 g of a,a,N-trimethyl-3,4-methylenedioxyphen-ethylamine hydrochloride (MDMP) with a mp of 206-208 °C. The NMR spectrum showed the a,(X-dimethyl pair as a singlet at 1.38 ppm. Anal. (C,3H18C1N03) C,H,N. 

This synthetic procedure, using the hydrochloride salt of the amine and sodium cyanoborohydride in methanol, seems to be quite general for ketone compounds related to 3,4-methylenedioxyphenylacetone. Not only were most of the MD-group of compounds discussed here made in this manner, but the use of phenylacetone (phenyl-2-propanone, P-2-P) itself appears to be equally effective. The reaction of butylamine hydrochloride in methanol, with phenyl-2-propanone and sodium cyanoborohydride at pH of 6, after distillation at 70-75 °C at 0.3 mm/ Hg, producedN-butylamphetamine hydrochloride (23.4 g from 16.3 g P-2-P). And, in the same manner with ethylamine hydrochloride there was produced N-ethyl-amphetamine (22.4 g from 22.1 g P-2-P) and with methy lamine hydrochloride there was produced N-methylamphetamine hydrochloride (24.6 g from 26.8 g P-2-P). The reaction with simple ammonia (as ammonium acetate) gives consistently poor yields in these reactions. 

H. P. Cady and R. Taft sought if electrolytic oxidations can occur in systems containing no oxygen, and found that with liquid ammonia as solvent, thallous iodide, cuprous iodide, hydrazobenzene, and methyl- and ethylamine hydrochlorides can be oxidized. The properties of soln. of salts, etc., in liquid ammonia were studied by F. W. Bergstrom, T. J. Webb, E. C. Franklin and C. A. Kraus, etc. 

C2H6NH2 HC1 (c). Gautier2 (see Berthelot151) measured the heat of solution of crystalline ethylamine hydrochloride. 

C2HbNH2 H+ (aq.). The value for aqueous ethylaminium ion is obtained from aqueous ethylamine hydrochloride. 

Alkylamino-4//-pyrido[ 1,2-a]pyrimidin-4-ones 371 (R = R2 = H R1 = Me, Et) were prepared when 2-chloro derivative 370 (R = H) reacted with methylamine hydrochloride or ethylamine hydrochloride in boiling ethanol for 24 hours in the presence of triethylamine (92JHC25). 

Clorobutiric acid dimethyl amide is dissolved in absolute benzene and heated to 110°-120°C with ethylamine in the autoclave. After cooling the ethylamine hydrochloride is filtered off, then the benzene solution is treated with water and freed from any dissolved ethylamine hydrochloride by means of potassium lye. After distillation of the benzene the 2-ethylaminobutyric acid dimethyl amide is rectified in vacuum. 

Common Name N-Demethylorphenadrine hydrochloride N-Methyl-2-[a-(2-tolybenzyl)oxy]ethylamine hydrochloride... 

SYNS BF 5930 BG 5930 BROCADISIPAL BROCASIPAL BS 5930 2-DIMETHYLAiMINOETHYL-2-METHYLBENZHYDRYL ETHERHYDROCHLORIDE N,N-DIMETHYL-2-(o-METHYL-a-PHENYLBENZYLO-XY)ETHYLAMINE HYDROCHLORIDE DISIPAL HYDROCHLORIDE MEPHENAMINE HYDROCHLORIDE MEPHENAMIN HYDROCHLORIDE... 

METHYLPHENYL)AZO)BENZENAMINE see DUH600 N,N-DLMETHYL-2-(o-METHYL-a-PHENYLBENZYLOXY) ETHYLAMINE HYDROCHLORIDE see OJWOOO... 

The reaction is not restricted to phosphorus, silicon, and boron compounds the tetrameric (NSEt) is, for instance, formed from ethylamine hydrochloride and sulfur dichloride (49). Nor is it restricted to nitrogen compounds the very stable cyclic phosphinoborines are formed by elimination of hydrogen from the dimethyl-phosphine borine complex (17). 

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