Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Ethanol esterification with

FIGURE 10.23 (See color insert following page 588.) Ethanol esterification with acetic acid comparison performances of different... [Pg.300]

Another appHcation of 4-chlorophenol is in the synthesis of a dmg, ethyl a, a-dimethyl-4-chlorophenoxy acetate [637-07-0] (60), used as a cholesterol-reducing agent. This synthesis involves reaction with acetone and chloroform, followed by ethanol esterification. [Pg.82]

Hydrolysis of the nitrile in 130 (obtained by an alkylation analogous to that used to prepare 126) affords the acid, 131. esterification with ethanol affords the analgesic agent, norpipa-none (132). ... [Pg.81]

The Ester Rule states that in the esterification of hydroxy acids of D-series with methanol, the shift takes place to right but in esterification with ethanol the shift to the right increases. [Pg.142]

The transesterification of cocaine to cocaethylene is an enzymatic reaction catalyzed by microsomal carboxylesterases and blocked by inhibitors of serine hydrolases [124][125], In Chapt. 3, we have discussed the mechanism of serine hydrolases, showing how a H20 molecule enters the catalytic cycle to hydrolyze the acylated serine residue in the active site of the enzyme. In the case of cocaine, the acyl group is the benzoylecgoninyl moiety (Fig. 7.9,d ), which undergoes esterification with ethanol according to Steps e and/ (Fig. 7.9). [Pg.412]

One of the early syntheses of meperidine (75) starts with the double alkylation of phenylacetonitrile with the bischloro-ethyl amine, 72. The highly lachrimatory nature of this material led to the development of an alternate synthesis for the intermediate piperidine (73). Alkylation of phenylacetonitrile with two moles of 2-chloroethylvinyl ether leads to the intermediate (69). This is then hydrolyzed without prior isolation to the diol, 70. Treatment with thionyl chloride affords the corresponding dichloro compound (71). This last is then used to effect a bis alkylation on methylamine, in effect forming the piperidine (73) by cyclization at the opposite end from the original scheme. Saponification to the acid (74) followed by esterification with ethanol affords the widely used analgesic meperidine (75) substitution of isopropanol for ethanol in the esterification affords properidine (76). ... [Pg.318]

Methyl />-ethylbenzoate was prepared from ethylbenzene (1 kg.), which was converted into jb-ethylacetophenone by adding aluminum chloride (792 g.), followed by acetyl chloride (462 g.), which was added with stirring at 0-5° over a period of 3 hours. The mixture was stirred for 1 hour longer, allowed to stand overnight, and washed with iced dilute hydrochloric acid. The ethylbenzene was removed by distillation, and the crude product was oxidized to p-ethylbenzoic acid with alkaline hypochlorite.4 Recrystallization of the crude acid from 95% ethanol yielded 350 g. (41%) of the pure acid m.p. 110-112°. Esterification with methanol in the presence of hydrogen chloride 4 yielded methyl />-ethylbenzoate (77-79%). [Pg.82]

A mechanism similar to that proposed by Mochida for the above-mentioned group of catalysts, though not so explicitely formulated, might also be valid for acetic acid—ethanol esterification over a H3P04/C catalyst [416]. According to the author, the adsorbed acid in a polymolecular film on the surface of the catalyst reacts with protonated molecules of the adsorbed ethanol. [Pg.355]

Considerably fewer kinetic studies were performed with reactants in the vapour phase than in the liquid phase. The second-order rate equation was only used for acetic acid—ethanol esterification at 130°C and 175° C on a KU-2 standard ion exchanger [444,445]. A semiempirical second-order rate equation with slight inhibiting effect of reaction products, viz. [Pg.359]

S)-(-)-2-Methyl-1 -butanol (GC purity > 99.5% [a]p -6.6 0.3° (ethanol, c 10) was purchased from Fluka Chemie AG. Esterification with (R)-(+)-3.3,3-trifluoro-2-methoxy-2-phenylpropionic acid (Mosher s acid)2 and subsequent fH and 19F NMR analyses at 300 MHz of the resulting ester showed an enantiomeric purity of (S)-(-)-2-methyl-1-butanol > 99%. [Pg.213]

Bowden94 studied the transmission of substituent effects through C=C in the esterification of 3-substituted acrylic acids with diazodiphenylmethane (DDM) and in the ionization of the same acids. The ap values of the substituents were used to characterize their electronic effects for Hammett-type correlations. In esterification with DDM at 30 °C, the p values of the trans acids and the cis acids were 1.682 and 1.772, respectively, in ethanol... [Pg.107]

The first McCasland s pseudo-sugar, pseudo-a-DL-talopyranose (P) was synthesized from 4-acetoxy-2,3-dihydroxy-5-oxo-cyclohexanecarboxylic acid (6) as follows [13]. Reduction of the oxo acid 6 with sodium borohydride and subsequent esterification with methanol and trifluoroacetic acid, followed by acetylation gave methyl (1, 2, 3, 4/5)-2, 3, 4, 5-tetraacetoxycyclohexanecarboxylate (7). Hydrogenation of 7 with lithium aluminium hydride and successive acetylation yielded pseudo-a-DL-talopyranose pentaacetate (8). Hydrolysis of 8 in ethanolic hydrochloric acid gave pseudo-a-DL-talopyranose 9 in 23% overall yield from 6 [1] (Scheme 6). [Pg.260]

The new technique is illustrated below with the same example (ethanol esterification) and using the results of the maximum conversion problem. For x D = 0.70, Mujtaba and Macchietto (1997) used 5th order polynomials to fit the data presented in Figures 9.3 and 9.5 a 3rd order polynomial to fit the data in Figure 9.4 and a Is1 order polynomial to fit the data in Figure 9.6 respectively. The resulting curves and the polynomial equations are shown in Figures 9.9-9.12. [Pg.286]

Fischer esterification is an equilibrium, and typical equilibrium constants for esterification are not very large. For example, if 1 mole of acetic acid is mixed with 1 mole of ethanol, the equilibrium mixture contains 0.65 mole each of ethyl acetate and water and 0.35 mole each of acetic acid and ethanol. Esterification using secondary and tertiary alcohols gives even smaller equilibrium constants. [Pg.964]

A cortisone synthesis using remote functionalization at an unactivated carbon centre has been achieved.97 Cortexolone (224) was converted into the 5a-H,3j3-OH derivative (formation of the bismethylenedioxy-compound followed by lithium-ammonia-ethanol reduction). Inversion98 of 3)8- to 3 -OH followed by esterification with m-iodobenzoic acid produced (225), which on irradiation in methylene chloride containing phenyl iodide dichloride gave the 9 a -chloro-derivative (not isolated). This was dehydrohalogenated and saponified by methanolic potash to yield (226) (75%) and thence, by further known steps, cortisone acetate. [Pg.307]

Peptide Modification lodination was carried out on a stainless steel probe target by adding 0.1 % aq. I2 (1 pi) to the dried peptide (ca. 1 pmol). The reaction was stopped after 1 minute by addition of ascorbic acid and the MALDI matrix, a-cyano cinnamic acid in excess. Esterification with ethanol was carried out using the method of Hunt et al. (15), where an acetylchloride and ethanol solution (1 6, v v) was added (5 pi) to the peptide dried in a microcentrifuge tube (ca. 1 pmol). After incubation for 15 minutes at room temperature a 2 mM p-mercaptoethanol (in ethanol) solution was added (1 pi) and the mixture was dried. The matrix, a-cyano-4-hydroxycinnamic acid (2 pi), was added to the micro tube and after 5 minutes 1 pi of this matrix was removed and applied to a target. [Pg.33]

In one process, the inventor has reported that sugars from oilseed meals are readily fermented to form ethanol (80). With soybeans, the concentration of fermentable sugars can constitute 12% of the meal weight. These sugars could readily be fermented to produce enough ethanol for esterification of oil from the seed. However, it is improbable that seeds with higher oil contents would produce sufficient ethanol from fermentation to esterify the oils present. [Pg.3220]


See other pages where Ethanol esterification with is mentioned: [Pg.391]    [Pg.134]    [Pg.119]    [Pg.299]    [Pg.303]    [Pg.303]    [Pg.315]    [Pg.138]    [Pg.322]    [Pg.322]    [Pg.349]    [Pg.366]    [Pg.164]    [Pg.734]    [Pg.10]    [Pg.11]    [Pg.18]    [Pg.57]    [Pg.112]    [Pg.130]    [Pg.139]    [Pg.220]    [Pg.3221]    [Pg.55]    [Pg.312]    [Pg.195]    [Pg.201]    [Pg.318]   
See also in sourсe #XX -- [ Pg.36 , Pg.349 , Pg.351 , Pg.357 , Pg.359 , Pg.359 , Pg.363 , Pg.363 , Pg.366 ]




SEARCH



Esterification with

Ethanol esterification

© 2024 chempedia.info