Cholesterol-reducing agents

Another appHcation of 4-chlorophenol is in the synthesis of a dmg, ethyl a, a-dimethyl-4-chlorophenoxy acetate [637-07-0] (60), used as a cholesterol-reducing agent. This synthesis involves reaction with acetone and chloroform, followed by ethanol esterification. 

Therapeutic Function Cholesterol-reducing agent Chemical Name 2,2 -(decamethylenedithio)diethanol Common Name -... 

Cholesterol-Reducing Agents. Hypercholesterolemia is well known as a major risk factor for coronary heart disease. In clinical practice, two main hypocholestrolemic agents are commonly used. One is the 3-hy-droxy-3-methylgrutaryl coenzyme A (HMG-CoA) reductase inhibitors (such as Lipitor) another is the bile acid sequestrants, such as cholestyramine and colestipol (97), which bind bile acid in the intestinal lumen and thus increase their excretion. The main drawback of... 

FIGURE 35-2 Reduction in coronary heart disease events in clinical trials is associated with the extent of plasma cholesterol lowering. As more potent cholesterol-reducing agents become available, will it be possible to reduce events... 

In ESI-MS, and also in APCI-MS, the appearance of the mass spectrum depends on the mobile-phase composition. In addition, the appearance of mass spectra may change by applying instruments from different manufacturers and/or with different ion source geometries. Some results with the cholesterol reducing agent simvastatin may serve as an example. In acetonitrile/water or acetonitrile/aqueous ammonium acetate (1 nunol/L, adjusted to pH 4.0), simvastatin shows [M+Na] (Sci-ex ionspray interface and API-Ill) [113]. Under similar mobile-phase conditions but on a different instrument (Sciex turboionspray and API-365), [M-i-H]+ and were most abundant. With 2 nunol/L ammonium acetate in the mobile phase, the [M+NH ]" actually is the most abundant ion, next to [M-i-H]+, [M-l-Na] and [M+K]+being present [114, 115]. Attempts to force the ionization toward the generation of [M -i-Na]+ by the addition of sodium acetate in the case of simvastatin compromised the performance of the method. 

Animal cholesterol reducer agent Methyl vinyl France 2,074,603 1971 Monsanto... 

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