Estrogen resveratrol

Gehm BD, McAndrews JM, Chien PY, Jameson JL. 1997. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci USA 94 14138-14143. 

Levenson AS, Gehm BD, Pearce ST, Horiguchi J, Simons LA, Ward JE 3rd, Jameson JL, Jordan VC. 2003. Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha. Int J Cancer 104 587-596. 

Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM. 2001. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 61 7456-7463. 

Chen ZH, Hurh YJ, Na HK, Kim JH, Chun YJ, Kim DH, Kang KS, Cho MH, Surh Y-J. 2004. Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. Carcinogenesis 25 2005-2013. 

Zahid M, Gaikwad NW, Ali MF, Lu F, Saeed M, Yang L, Rogan EG, Cavalieri EL. 2008. Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol. Free Radic Biol Med 45 136-145. 

Gebhardt, R. and Beck, H. 1996. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte culture. Lipids 31, 1269-1276. Gehm, B.D., McAndrews, J.M., Chien, P.Y., and Jameson, J.L. 1997. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for estrogen receptor. Proc. Natl Acad. Sci. 94, 14138-14143. 

Bowers JL, Tyulmenkov W, Jemigan SC, Klinge CM (2000) Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology 141 3657-3667... 

Gehm BD, Levenson AS, Liu H, Lee EJ, Amundsen BM, Cushman M, Jordan VC, Jameson JL (2004) Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors role of AF-1 and AF-2. J Steroid Biochem Mol Biol 88 223-234... 

Coronary heart disease and atherosclerosis are major contributors to morbidity and mortality in the United States and other developed countries. Epidemiological studies suggest that decreased mortality from coronary heart disease is associated with moderate consumption of alcohol, and especially of red wine [7], Numerous studies indicate that resveratrol inhibits platelet aggregation [8-10, 12, 16, 54, 55], alters eicosanoid synthesis [15, 55], modulates lipoprotein mechanisms [14, 56-58], inhibits vascular smooth muscle cell proliferation [59], and acts as an estrogen receptor agonist [60]. On the other hand, at least one earlier study indicated that it promoted atherosclerotic development, rather than protected against it, by a mechanism that appeared to be independent of observed... 

Resveratrol has been shown to inhibit proliferation, induce differentiation, and enhance the expression of adhesion molecules (GDI la, GDI lb, GDIS, GD54) in a variety of myeloid leukemia cell lines [144]. The inhibitory effect of resveratrol on cell survival and proliferation of human breast cancer cells was shown to be estrogen receptor dependent [145]. Other studies indicated that it was very effective in inhibiting growth of 4T1 breast cancer cells in culture but had little effect on 4T1 tumor cell growth in mice [146]. In stark contrast, resveratrol was tested against mammary tumors induced by 7, 12-dimethylbenz(a)anthracene (DMBA) in rats [147]. In this case, reductions in incidence, multiplicity, and latency period of tumor development were observed. Additional... 

El-Mowafy, A.M. and AUcjalaf, M., Resveratrol activates adenylcyclase in human breast cancer cells a novel, estrogen receptor-independent cytostatic mechanism. Carcinogenesis, 24, 869,... 

Chemoprevention is an emerging and promising approaeh to control human cancer. Several natnral products have been proven to have potentials as anticancer agents. Resveratrol is one such compound. Recently, increasing interest has focused on examining the effect of resveratrol in breast cancer prevention and treatment. The present review summarizes the recent studies on the role of resveratrol in cancer prevention and therapy, especially in human breast cancer, that provide new insights into the molecular mechanisms of resveratrol. The estrogenic activity of resveratrol, as well as its in vitro and in vivo antiproliferative and chemoprotective activities, will be discussed here. 

RESVERATROL ESTROGEN OR ANTIESTROGEN IN MAMMARY EPITHELIAL CELLS ... 

FIGURE 26.2 Structural similarity between /raw5-resveratrol and other estrogen agonists. 

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