1.2- Epoxy-3-phenoxy propane

One approach to introduce an anionic moiety onto dextran is sulfopropylation. In combination with a hydrophobic modification, sulfopropylation was utilised for manufacture of anionic amphiphilic dextran ethers. The derivatives were synthesised in two steps. Dextran was reacted with 1,2-epoxy-3-phenoxy propane in aqueous NaOH solution (Fig. 35) or in DMSO using TBAH instead of NaOH. The subsequent step is the conversion with 1,3-propane sultone in DMSO (Fig. 37). 

Synonyms/Trade Names 1,2-Epoxy-3-phenoxy propane Glycidyl phenyl ether PGE Phenyl 2,3-epoxypropyl ether ... 

N,N-dimethylhexyl amine 1,2-epoxy-3-phenoxy-propane Various carboxylic ... 

The starting material 1,2-epoxy-3-[p-(/3-methoxyethyl)-phenoxy] -propane was obtained from p-(/3-methoxyethyl)-phenol which was reacted with epichlorohydrin whereafter the reaction product was distilled at 118°C to 128°C at a pressure of 0.35 mm Hg. 

Metoprolol Metoprolol, l-(wo-propylamino)-3-[4 (2-methoxyethyl)phenoxy]-2-propanol (12.1.5), is synthesized by reacting 4-(2-methoxyethyl)phenol with epichlorhy-dride in the presence of a base, isolating l,2-epoxy-3-[4 (2-methoxyethyl)phenoxy] propane (12.1.4), the subsequent reaction of which, analogous to that described before, with jio-propylamine, gives an opening of the epoxide ring and leads to the formation of metoprolol (12.1.5) [7,8]. 

Epoxy-3-(p-(i3.methoxyethyl)-phenoxy] -propane (16.7 g) was dissolved in 50 ml isopropanol and mixed with 20 ml isopropylamine. The mixture was heated In an autoclave on... 

We have already discussed the contribution of some side reactions in Sect. 1 and 4.2. In Sect. 4.2.4. we limit our discussion to the system benzoic acid/l,2-epoxy-3-phenoxy-propane/dodecyl dimethylamine. The kinetics obeys a law whidi depends on the nature of the reaction solvent. 

By analogy to similar reactions observed with various acidic proteases (for example 41-43), it is highly likely that the reaction between renin and aliphatic diazocompounds involve the 3-carboxyl group of an aspartyl residue. Furthermore, renin is inactivated by epoxides such as l,2-epoxy-3-phenoxy-propane (40), which is also an inactivator of acidic proteases. These results, together with the fact that the acidic protease inhibitor pepstatin is a potent inhibitor of renin, have led Inagami and Misono (38) and Mckown and Greger-man (39) to propose that renin can be classified as an acidic protease,... 

Phenol, 4,4 -isopropylidenedi- Pluracol 245 Propane, 2,2-bis(p-hydroxyphenyi)- Rikabanol Uoar bisphenol A Ucar bisphenol HP. intermediate in manufacture of epoxy, polycarbonate, phenoxy, polysulfone, polyester resins, flame retardant, rubber chemicals fungicide. Solid mp = 147.9° bpio 250° Am = 226, 248, 277 nm 15000,25900,1310, MeOH) insoluble in H2O soluble in organic solvents LD50 (rat orl) = 3250 mg/kg. Aristech Mitsui Petroleum Mitsui Toatsu Shell. 

Propane, l,2-epoxy-3-(l-naphthyloxy)-, polyether —, l,2-epoxy-3-(2-naphthyloxy)-, polyether l,2-epoxy-3-phenoxy-, polyether... 

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