1,3-Propane Sultone

Data were last reviewed in lARC (1974) and the compound was classified in lARC Monographs Supplement 7 (1987). 

1120-71-4 Chem. Abstr. Name-. 1,2-Oxathiolane, 2,2-dioxide 

Synonyms-. 3-Hydroxy-l-propanesulfonic acid, y-sultone propane sultone 

2 Structural and molecular formulae and relative molecular mass 

No infonnation on the global production of 1,3-propane sultone was available to the Working Group. 

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Several other types of monomers have been successfully used for the spontaneous copolymerization266). For MN, 2-oxazine, N-benzyliminotetrahydrofuran, N-ben-zylidene aniline, dioxaphospholanes and 1,3,3-trimethylazetidine were used and as Mg, succinic anhydride, propane sultone, acrylic acid and acrylamide were used268"273). 

Selective betainization of the PDMAEMA block of PDMAEMA-PDEAEMA, PDMAEMA-PDPAEMA, and PDMAEMA-PMEMA copolymers by propane-sultone resulted in thermosensitive systems, as reported by Armes and coworkers [160,188]. 

Synonyms 1,3-Propane sultone 3-hydroxy-l-propanesulfonic acid sultone 1,2-oxathrolane 2,2-dioxide... 

Toxieology. Propane sultone is a carcinogen in experimental animals and a suspected human carcinogen. No human data are available. ... 

Propane sultone is genotoxic in a wide variety of in vitro assays it also induces DNA strand breaks in vivo in rodents. ... 

The lARC has determined that there is sufficient evidence for carcinogenicity of propane sultone in experimental animals and that it is possibly carcinogenic to humans. ... 

Ulland B, et al Carcinogenicity of the industrial chemicals propylene imine and propane sultone. Nature 230 460-461, 1971... 

Van Durren BL, et al Carcinogenicity of isoesters of epoxides and lactones Aziridine ethanol, propane sultone and related compounds. J Natl Cancer Inst 46 143-149, 1971... 

Druckery H, Kruse H, Preussman R Propane sultone, a potent carcinogen. Nautrwiessen-schaften 55 449, 1968... 

Dichloroethyl ether (bis(2-chloroethyl) ether) 1,3-Propane sultone... 

Siunskas, K.C., Kateley, S.A., Tower, J.E., Maher, V.M., and McCormick, J.J. (1981). Induction of anchorage-independent growth in human fibroblasts by propane sultone, Cancer Res. 41,1620. 

Rodrigues et al. (4) prepared polymeric ionic liquid derivatives, (VI), by condensing poly(4-vinylpyridine) with propane sultone and products used as antidye transfer agents. 

The step 2 product (29.1 g) was dissolved in 500 ml of M/V-dimcthylacetamidc by heating the mixture to 100°C and then treated with lithium hydride (258 mmol) followed by 2 hours of stirring. This solution was then treated with propane sultone (258 mmol) and then stirred for 8 hours. The insoluble components in the reaction mixture were collected by filtration and the solution added to 1 M hydrochloric acid to cause the polymer to precipitate. The precipitated polymer was washed with 1M hydrochloric acid and distilled water until the pH became neutral. The polymer was dried at 75°C and 38.2 g of product isolated as a powder. 

Propane sultone has been used as a chemical intermediate to introduce the propyl-... 

The American Conference of Governmental Industrial Hygienists (ACGIH) (1997) has not proposed any occupational exposure limit for 1,3-propane sultone in workplace air but does list it as an animal carcinogen. Australia, Belgium, Finland, France, Germany, Sweden and Switzerland list 1,3-propane sultone as a probable human carcinogen (International Labour Office, 1991). 

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