Phenoxy-propan-2-ol

14 in water soluble in polar and non-polar solvents insoluble in mineral oil 

According to the indications of Fiedler (1989) the special merits of phenoxyisopropanol are good skin and eye compatibihty. 

Because of its broad spectrum of effectiveness and its favourable dermatological properties l-phenoxy-propan-2-ol is mentioned in the EC hst of preservatives allowed for he protection of cosmetic products with a maximum concentration of 1% (for rinse-off products only). 

As can be seen from the minimum inhibition concentrations listed in Table 7. the mixture exhibits a moderate antimicrobial activity in consequence it is mainly used in combination with other microbicides. Its activity is largely independent of pH. 

Toxicity data for the Phenoxypropanol mixture (Source BASF Specialty Chemicals) 

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To a solution of 1 gramm equivalent (g-eq.) of l-bromo-3-[2-(tetrahydrofuran-2-yloxy)phenoxy]propan-2-ol in 30 ml of ethanol is added 1 g-eq. of t-butylamine, the mixture is refluxed for 6 hours, and then the ethanol is distilled off. The residue is dissolved in benzene and the solution is extracted twice with 5% oxalic acid. The aqueous extract is made alkaline with potassium hydroxide and the isolated oil is extracted with benzene. The benzene extract is dried over potassium carbonate and the benzene is distilled off to give of oily l-(t-butylamino)-3-(o-((tetrahydrofurfuryl)oxy)phenoxy)-2-propanol. The corresponding acid fumarate melts at 128°-132°C. 

Erythro-1-(4 -hydroxy-3 -methoxyphenyl)-2-(2" -methoxy-4"-(T"-(E-)-propenyl) phenoxy-propan-1-ol... 

C18 3-[2,3-Dichloro-4-(2-thenoyl) phenoxy]-propan-l-ol 5-hydroxylation Phenobarbital Sulfaphenazole derivative"" ... 

Propan-1 -ol Erythro-2-(4-allyl-2-methoxy-phenoxy)-1 -(4-hydroxy-3 Hattori et al. (1987b)... 

Propan-1 -ol-Threo-1 -(4-hydroxy-3,5-dimethoxy phenyl)-2-(2methoxy-4-(1 -t-propenyl)-phenoxy... 

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