Ovarian cancer epithelial tumors

The three major pathologic categories of ovarian tumors include sex-cord stromal, germ cell, and epithelial. About 85% to 90% of ovarian cancers are of epithelial origin. 

Scotton CJ, Wilson JL, Scott K, et al. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 2002 62 5930-5938. 

Recently, Polychronopoulou45 examined tobacco, ethanol, and coffee as risk factors for ovarian cancer in Greek women in a hospital-based case-control study with data collected from 1989 to 1991. Cases were 189 women who were residents of Greater Athens and less than 75 years old with histologically confirmed common malignant epithelial tumors of the ovary. Controls were female residents of Greater Athens, less than 75... 

While the risk that hormone replacement therapy may cause endometrial tumors has been widely discussed, less attention has been given to the possibility that it could increase the risk of epithelial ovarian cancer. Since cancer of the ovary has some risk factors in common with endometrial cancer (notably low parity and obesity), this possible risk needs to be considered, especially in view of the fact that the endometrioid epithelial type of ovarian tumor is histologically so similar to adenocarcinoma of the endometrium. 

Malignant cartilage tumor Non-small-cell lung carcinoma Osteosarcoma Ovarian surface epithelial neoplasms Prostate cancer... 

Federici, M. F., Kudryashov, V., Saigo, P. E., Finstad, C. L., and Llyod, K. O. 1999. Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy Serous and mucinous tumor exhibit distinctive patterns of expression. Int. J. Cancer 87 193-198. 

Hempling RE. Tumor markers in epithelial ovarian cancer. Obstet Gynecol Clin North Am 1994 21 41-61. 

FIGURE 18.24 Many non-mucinous ovarian epithelial tumors, particularly serous tumors, exhibit positive staining for CA125. This microscopic serous carcinoma, found in a woman with a family history of ovarian cancer, illustrates the typical strong membranous staining pattern. 

Hylander B, Repasky E, Shrikant P, et al. Expression of Wilms tumor gene (WTl) in epithelial ovarian cancer. Gynecol Oncol. 2006 101 12-17. 

Breast and ovarian cancer share responsiveness to steroid hormones, and incidence of the vast majority of tumors in the epithelial rather than the stromal component. In addition, these diseases appear to share etiologic factors Women with one kind of tumor have an increased risk of developing the other type of tumor. Whereas normal ovarian tissue does not overexpress ErbB-... 

The synthetic pirimidine, 5-fluouracil (5-FU), is used in the treatment of a variety of epithelial tumors including, colorectal, breast cancer, ovarian, head, and neck cancers. 5-FU enters tumor cells by a facilitated nucleobase transporter and is converted into active metabolites (5 -fluoro-2 -deoxyuridine) by a complex metabolic pathway that interferes with both DNA and RNA syntheses. Of particular interest is the conversion of 5-FU to 5 -fluoro-2 -deoxyur-idine (5-FUdR) and subsequent phosphorylation by thymidine kinase to the active metabolite 5 -fluoro-2 -DUMP (5-FdUMP). Unfortunately, the response rate of patients receiving 5-FU-based chemotherapy is relatively poor, varying between 10 and 30%. To further evaluate, 5-FU labeled with F (5- FU) has been used in PET studies to understand the factors behind this strong interindividual variability. As 5- FU is biochemically identical to 5-FU, PET has been used for quantitative pharmacokinetic measurements of 5- FU in human and animal models. 

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