Extra-cellular signal-regulated kinase

Deoxycholic acid has also been demonstrated to activate other pivotal oncogenic pathways in CRC cells in vitro including p-catenin/T-cell factor-mediated transcription, extra-cellular signal-regulated kinase activation downstream of the epidermal growth factor receptor and Jun-N-terminal kinase... 

Cai H, Li Z, Davis ME, Kanner W, Harrison DG, Dudley SC. Jr 2003. Akt dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extra-cellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Mol Pharmacol 63 325-331. 

---