Pemphigus vulgaris

Mimouni D, Anhalt GJ, Cummins DL, Kouba DJ, Thome JE, Nousari HC. (2003) Treatment of pemphigus vulgaris and pemphigus foliaceus with mycophenolate mofetil. Arch Dermatol 139 739-742. 

Topical corticosteroids are most useful in inflammatory dermatoses, such as eczematous dermatitis and psoriasis they may also be helpful in other skin diseases that have a prominent inflammatory component, such as autoimmune blistering diseases (e.g., bullous pemphigoid and pemphigus vulgaris) and lupus erythematosus. 

Acarbose may also have caused pneumatosis cystoides intes-tinalis in a 55-year-old woman with pemphigus vulgaris (52). 

Maeda A, Yokoi S, Kunou T, Murata T. [A case of pneumatosis cystoides intestinalis assumed to be induced by acarbose administration for diabetes mellitus and pemphigus vulgaris.JNippon Shokakibyo Gakkai Zasshi 2002 99(ll) 1345-9. 

M19. Moncada, B., Kettelsen, S., Hemandes-Moctezuma, J. L., and Ramirez, F. Neonatal pemphigus vulgaris Role of passively transferred pemphigus antibodies. Clin. Res. 28, 251A (1980). 

Butt A, Burge SM. Pemphigus vulgaris induced by captopril. Dermatology 1993 186 315. 

Fellner MJ, Mark AS. Penicillin- and ampiciUin-induced pemphigus vulgaris. Int J Dermatol 1980 19(7) 392-3. 

A patient taking bucillamine developed an eruption that had features of both pemphigus foliaceus and pemphigus vulgaris and was associated with glomerulonephritis (13). 

Wilson JP, Keren JF, Daniel RC 3rd, Chapman SW. Cefadroxil-induced ampicillin-exacerbated pemphigus vulgaris case report and review of the literature. Drug Intell Clin Pharm 1986 20(3) 219-23. 

Wolf R, Dechner E, Ophir J, Brenner S. Cephalexin. A nonthiol drug that may induce pemphigus vulgaris. Int... 

Pemphigus vulgaris possibly triggered by cilazapril has been reported (4). 

Orion E, Gazit E, Brenner S. Pemphigus vulgaris possibly triggered by cilazapril. Acta Dermatol Venereol 2000 80(3) 220. 

Ogata K, Nakajima H, Ikeda M, Yamamoto Y, Amagai M, Hashimoto T, Kodama H. Drug-induced pemphigus foliaceus with features of pemphigus vulgaris. Br J Dermatol 2001 144(2) 421-2. 

Thami GP, Kaur S, Kanwar AJ. Severe childhood pemphigus vulgaris aggravated by enalapril. Dermatology 2001 202(4) 341. 

There is a recognized association between the use of ACE inhibitors and the development of pemphigus vulgaris, for... 

A 64-year-old woman with insulin-dependent diabetes mellitus and pemphigus vulgaris controlled by deflaza-cort 12 mg/day was given fosinopril 10 mg/day for hypertension. Within 1 month her skin lesions worsened and an indirect immunofluorescence test became positive. Fosinopril was withdrawn and her skin lesions improved without modification of her steroid regimen 10 months later the immunofluorescence test was negative. 

A 53-year-old woman with rheumatoid arthritis who had reacted to D-penicillamine treatment by developing myasthenia gravis was given gold instead and 12 months later developed pemphigus vulgaris (60). 

Ahmed AR. Intravenous immunoglobuhn therapy in the treatment of patients with pemphigus vulgaris unresponsive to conventional immunosuppressive treatment. J Am Acad Dermatol 2001 45(5) 679-90. 

Colonna L, Cianchini G, Frezzolini A, De Pita O, Di Leila G, Puddu P. Intravenous immunoglobulins for pemphigus vulgaris adjuvant or first choice therapy Br J Dermatol 1998 138(6) 1102-3. 

An active amide group on metamizole has been shown to cause pemphigus vulgaris (12,13). 

Mycophenolate has also been studied in various chronic inflammatory disorders, such as rheumatoid arthritis, pemphigus vulgaris, and psoriasis. In 70 patients with chronic active Crohn s disease, mycophenolate plus glucocorticoids produced benefit on disease activity comparable to azathioprine plus glucocorticoids (7). Two of the 35 patients randomized to mycophenolate had significant adverse effects that required drug withdrawal, namely rashes and vomiting. 

Two cases of pemphigus vulgaris, one aggravated and one induced by nifedipine, have been described (34). 

A 54-year-old woman with an 8-year history of pemphigus vulgaris had a flare-up of her disease, refractory to oral glucocorticoids, after taking nifedipine for 2 years for hypertension. The nifedipine was withdrawn and she was given high-dose immunosuppressant treatment with prednisone and azathioprine. The lesions subsided promptly and cleared totally within several weeks. 

A 68-year-old woman had a bullous eruption of pemphigus vulgaris after antihypertensive treatment with nifedipine. She was given high-dose systemic glucocorticoids. However, she was unresponsive and nifedipine was finally withdrawn. Although new lesions did not appear, she died a few days later with uncontrollable sepsis. 

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