Drug rash

Adverse effects include flushing, headache, dizziness, methaemoglobinaemia and drug rash. 

Jackson H, Vion B, Levy PM. Generalized eruptive pustular drug rash due to cephalexin. Dermatologica 1988 177(5) 292. ... 

Efavirenz can cause an allergic syndrome called the DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms). It is a life-threatening reaction that typically includes a rash, fever, lymphadenopathy, hepatitis, interstitial nephritis, pneumonia, myocarditis, and hematological abnormalities, particularly eosinophi-lia and a mononucleosis-like atypical lymphocjdosis. The DRESS syndrome has been described in an HIV-infected woman taking efavirenz (20). 

Paily R. Quinolone drug rash in a patient with infectious mononucleosis. J Dermatol 2000 27(6) 405-6. 

Although the various retinoids have similar toxicity profiles, they differ in the extent to which they affect various body systems. Cutaneous and mucous membrane symptoms (up to 70%) are by far the most prominent adverse effects patients who use isotretinoin have a 50% incidence of conjunctivitis and irritation of the eyes. Musculoskeletal symptoms occur in up to 15% of users. Hypersensitivity reactions are rare and consist of occasional drug rashes. The occurrence of sarcomas in patients treated with isotretinoin may well be a chance finding (SEDA-21, 164) retinoids may prevent or even cure certain malignancies (20). All the retinoids are strongly teratogenic (21-23). 

Hypersensitivity reactions to retinoids are rare and consist of occasional drug rashes. 

Hypersensitivity to barbiturates can result in a life-threatening syndrome called the Drug, Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome with a mortality of 10%. In persons developing hypersensitivity to barbiturates, there is a potential of cross-sensitivity with other aromatic antiepileptics, such as phenytoin and carbamazepine. 

The DRESS syndrome is an acronym for Drug Rash with Eosinophilia and Systemic Symptoms. It is also known as the Drug-Induced Pseudolymphoma and Drug Hypersensitivity Syndrome. The symptoms of DRESS syndrome usually begin I to 8 weeks after exposure to the offending drug. Common causes include carbamazepine, phenobarbital, phenytoin, terbinafine, and valproic acid. 

Bocquet H, Bagot M, Roujeau JC (1996) Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms DRESS). Semin Cutan Med Surg, 15 250-257. 

Vancomycin is highly associated with adverse infusion-related events. These are especially prevalent with higher doses and a rapid infusion rate. A rapid infusion rate has been shown to cause anaphylactoid reactions, including hypotension, wheezing, dyspnea, urticaria, and pruritus. A significant drug rash (the so-called red man syndrome) also can occur. These events are much less frequent with a slower infusion rate. 

Drug (-Induced) Hypersensitivity Syndrome (DHS or DiHS) or Drug Rash with Eosinophilia and Systemic Symptoms (DRESS)... 

Johnson-Reagan L, Bahna SL (2003) Severe drug rashes in three siblings simultaneously. Allergy... 

Allergic reactions to adenophora, including drug rash and asthma, have been reported (Bensky et al. 2004). 

Allergic reactions to longan have been reported, with one case producing an allergic drug rash with vertigo and... 

Improper use of American ginseng is reported to cause side effects such as headache, weakness, apathy, aversion to cold, distended abdomen, vomiting, and delayed menstruation. Allergic reactions including asthma and drug rashes have been reported (Bensky et al. 2004). 

Although described more than 90 years ago, fixed drug eruptions are little known outside the world of dermatology. Whereas other allergic drug rashes exhibit a... 

Our results agree approximately with those obtained by weighted attributions by Shapiro et al. (1969), who obtained percentages for drug rash with ampicillin of 7.7%, with other penicillins of 2.7%, and in patients not given these drugs of 1.8%. They used the above-mentioned corrections of time of exposure. The 1.8% basic frequency in their paper was discounted. Cotrimoxazole had not been introduced at that time. 

Shapiro S, Slone D, Siskind V, Lewis GP, Jick H (1969) Drug rash with ampicillin and other penicillins. Lancet 2 969-972... 

Brown GL, Kanware BS (1967) Drug rashes in glandular fever. Lancet 2 1418 Budd MA, Parker CW, Norden CW (1964) Evaluation of intradermal skin tests in penicillin hypersensitivity. JAMA 190 203... 

In one case, drug rash with eosinophilia and systemic symptoms (DRESS) attributed to carbamazepine was successfully managed by switching to phenobarbital [125 ]. 

Skin A man developed overlapping features of drug rash with eosinophilia and systemic symptoms (DRESS), toxic epidermal necrolysis, and Stevens-Johnson syndrome while taking phenytoin [240" ]. A 46-year-old man taking phenytoin developed Stevens-Johnson syndrome, starting in three well-demarcated areas on his scalp, chest, and back, corresponding to ports of... 

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