Weighted Attributions

Our results agree approximately with those obtained by weighted attributions by Shapiro et al. (1969), who obtained percentages for drug rash with ampicillin of 7.7%, with other penicillins of 2.7%, and in patients not given these drugs of 1.8%. They used the above-mentioned corrections of time of exposure. The 1.8% basic frequency in their paper was discounted. Cotrimoxazole had not been introduced at that time. 

The frequencies of the reaction by weighted attributions, in the overlapping fields are distributed to the non-overlapping fields according to their proportions (Arndt and Jick 1976). This can be done as long as no drug interactions occur. 

The methods of Euler-Venn diagrams or weighted attributions can be used only with a large number of observations. For both methods the result can be expressed either as a frequency in terms of the percentage of patients exposed or, as 

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Fig. 7.34 Gains in weight of 347S31 steel in air at 650°C with various periodic additions of sodium chloride. Stepped curves show quantity of NaCl added, broken curves show gains in weight attributable to oxidation...

The coefficients appearing in the first row of the matrix A provide the weight attributed to each of the four data points that determine the interpolated Doint indicated bv the arrow in Fie. 3b. The elements in the second and third... 

The sample temperature was raised at a rate of 20°C/minute maintaining a nitrogen atmosphere. A considerable loss of weight, attributed to a loss of sorbed solvent (s. above), is observed below 130 °C. Sample decomposition obviously starts after melting. 

Hepatic Effects. No information is available on the hepatic effects of HDI in humans. Limited information exists on these effects in laboratory animals and is confined to inhalation studies. One study of intermediate-duration showed decreased liver weights in female rats dosed at 0.3 ppm (Mobay Corporation 1984) however, 2 studies of longer durations and slightly lower inhaled doses showed no ehanges in liver weights attributable to HDI toxieity (Mobay Corporation 1988, 1989). It appears that the ehanges in liver weights are a transitory phenomenon in laboratory animals. 

Table IV. Weighted Attribute Interaction for Three Clusters...

Obesity— A chronic, metabolic condition of excess body weight attributable to fat. Obesity is defined by some as a body weight that is 30% above an ideal value given age, gender, and height. 

DSC studies on modified poly(urethaneurea) blood sacs Liu et al. [48] used DSC to investigate the stability of modified poly(urethaneurea) blood sacs implanted for up to 160 days. For sacs tested both in vivo and in vitro, there was no significant difference which was confirmed by ATR-FTIR, indicating chemical stability. There were however variations in the molecular weight attributed to chain extensions in vivo. 

The EPA explained its preferred methods for representing polymers on the Inventory in its 1995 Toxic Substances Control Act Inventory Representation for Polymeric Substances, and began by defining what substances can be hsted on the Inventory as polymers.For this purpose, EPA defined polymers as sequences of one or more types of monomer units, where a monomer unit is the reacted form of a monomer bonded to two or more other molecules. A polymer must also have a distribution of molecules of different molecular weights attributable primarily to different numbers of monomer units in the molecules. If all the molecules of a specific substance always have the same chain length then that substance is described on the Inventory as a specific substance with a defined structure and molecular weight, and not as a polymer. There are limited exceptions to this rule. Some chemicals that chemists may consider to be polymers do not fall within this definition because they do not have a distribution of molecular weights. 

Statistical weights attributable to side chain conformations may be evaluated according to the scheme ... 

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