Drug rash with eosinophilia sulfasalazine

Rosenbaum J, Alex G, Roberts H, Orchard D. Drug rash with eosinophilia and systemic symptoms secondary to sulfasalazine. J Paediatr Child Health 2010 46 193-6. 

A 60-year-old woman with polyarthritis taking sulfasalazine developed a drug rash with eosinophilia and systemic symptoms (DRESS) with acute liver failure after taking vancomycin for 2 days [99" ]. After liver transplantation and initial recovery, hepatitis recurred. Lymphocytes and eosinophils were detected post-mortem in the... 

Immunologic There have been further reports of drug rash with eosinophilia and systemic symptoms (DRESS) in patients taking sulfasalazine, a 47-year-old white Brazilian woman who developed DRESS after 8 weeks [104" ], a 60-year-old man with polyarthritis who also developed fulminant liver failure after additional vancomycin treatment [lOS ], and a 68-year-old woman in whom the reaction may have been precipitated by the addition of sulbactam -f ampicillin [lob ll. In another case, drug-induced hypersensitivity syndrome was associated with reactivation of an infection with human herpesvirus-6 in a 15-year-old boy with juvenile rheumatoid arthritis who was taking sulfasalazine [107 ]. 

Bahat G, Celik HG, Tufan F, Saka B. Drug rash with eosinophilia and systemic symptoms syndrome induced by sulfasalazine. Joint Bone Spine 2010 77(1) 87-8. 

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