Quinidine drug monitoring

Drug interactions Serious and/or life-threatening drug interactions could occur between amprenavir and amiodarone, lidocaine (systemic), tricyclic antidepressants, and quinidine. Concentration monitoring of these agents is recommended if these agents are used concomitantly with amprenavir. 

When quinidine is administered p.o. at a dose rate of 22 mg/kg every 2h, therapeutic drug monitoring is ideally performed after the fourth to sixth dose, with serum obtained 1 h after the administration of quinidine. The therapeutic range is 2-5 i.g/ml (Reef 1999) and signs of toxicity are commonly seen when plasma concentrations exceed 5 xg/ml (Reef et al 1995). 

Quinidine Therapeutic drug monitoring recommended may require quinidine dose increase. 

Quinidine Similar class lA antiarrhythmic effect, leading to EKG parameter changes (e.g., longer QRS) Palpitations, bradycardia Need frequent monitoring of EKG parameters when drugs are used in combination Glassman and Preud homme, 1993... 

Severe hypotension can follow too-rapid intravenous infusions of quinine or quinidine. Electrocardiographic abnormalities (QT interval prolongation) are fairly common with intravenous quinidine, but dangerous arrhythmias are uncommon when the drug is administered appropriately in a monitored setting. 

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