Pharmacokinetics therapeutic drug monitoring

Therapeutic drug monitoring (TDM) or applied pharmacokinetics is the use of serum drug concentrations to optimize therapy.28,36,37 Non-AIDS patients with drug-susceptible TB... 

Therapeutic drug monitoring The process of using drug concentrations, pharmacokinetic principles, and pharmacodynamic criteria to optimize drug therapy in individual patients. 

M Mayersohn. Special pharmacokinetic considerations in the elderly. In WE Evans, JJ Schentag, WJ Jusko, eds. Applied Pharmacokinetics Principles of Therapeutic Drug Monitoring. 3rd ed. Vancouver, WA Applied Therapeutics, 1992, pp. 9-1-9-43. 

Slish, J.C. et al. 2006. Update on the pharmacokinetic aspects of antiretroviral agents Implications in therapeutic drug monitoring. Curr Pharm Des. 12 1129. 

Tricyclic antidepressants Despite the numerous publications over the past 30 years on the determination of the TCAs (Tricyclic Antidepressants) by HPLC to establish possible therapeutic windows, both therapeutic drug monitoring and pharmacokinetic calculations have revealed there is considerable variation (10- to 50-fold) in plasma concentrations between individuals with these drugs. The plasma concentrations are usually in the range of 50-300 ng/ml. 

Shaw LM, Korecka M, De Nofrio D, Brayman KL. (2001) Pharmacokinetic, pharmacodynamic and outcome investigations as the basis for mycophenolic acid therapeutic drug monitoring in renal and heart transplant patients. Clin Biochem 34 17-22. 

Burton ME, Shaw LM, Schentag JJ, Evans WE, editors. Applied pharmacokinetics pharmacodynamics, principles of therapeutic drug monitoring. Baltimore (MD) Lippincott Williams Wilkins 2006. 

Burke MJ, Preskorn SH (1999) Therapeutic drug monitoring of antidepressants cost implications and relevance to clinical practice. Clin Pharmacokinet 37 147-165 Cardon LR, Abecasis GR (2003) Using haplotype blocks to map hiunan complex trait loci. Trends Genet 19 135-140... 

Rowland M and Tozer TN. Clinical Pharmacokinetics (3rd ed.). Baltimore Williams Wilkins, 1995. Schumacher GE. Therapeutic Drug Monitoring. Norwalk, CT Appleton Lange, 1995. 

Battino D, Crod D, Rossini A, et al. Serum carbamazepine concentrations in elderly patients a case-matched pharmacokinetic evaluation based on therapeutic drug monitoring data. Epilepsia 2003 44 923-929. 

Merle, Y. and Mentre, F. (1999) Optimal sampling times for Bayesian estimation of the pharmacokinetic parameters of nortriptyline during therapeutic drug monitoring. / Pharmacokinet Biopharm 27 85-101. 

Milsap, R.L. and Szefler, S.J. (1986) Special pharmacokinetic considerations in children. In Evans, W.E., Schentag, J.J., and Jusko, W.J., eds. Applied Pharmacokinetics. Principles of Therapeutic Drug Monitoring. Spokane, WA Applied Therapeutics, Inc., pp. 294-330. 

Burke MJ, Preskorn SH. Therapeutic drug monitoring of antidepressants cost implications and relevance to clinical practice. Clin Pharmacokinet 1999 37 147-165. 

TABLE 3-3. Pharmacodynamic and pharmacokinetic characteristics of a drug that predict ciinicai usefulness of therapeutic drug monitoring... 

THERAPEUTIC DRUG MONITORING RELATING PHARMACOKINETICS PHARMACODYNAMICS... 

Dvorchik, B.H., and E.S. Vesell. 1976. Pharmacokinetic interpretation of data gathered during therapeutic drug monitoring. Clin. Chem. 22(6) 868-878. 

Schramm et al. [48] described a gas chromatographic method for determination of vigabatrin enantiomers in plasma. The method used a double derivatization step on a megabore Chirasil-Val capillary column and thermionic specific detection. The calibration graphs for the R-(-) and (S)-(+)-enantiomers were linear over the concentration range of 1.0-200 and 0.5-100 fig/ml, respectively. The assay was suitable for pharmacokinetic studies and routine therapeutic drug monitoring in humans. 

Therapeutic Drug Monitoring Relating Pharmacokinetics Pharmacodynamics... 

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