Therapeutic drug monitoring timing

The most commonly used corticosteroids are methylpred-nisolone (IV and oral) and prednisone (oral), although prednisolone and dexamethasone also have been shown to be effective for organ transplantation. Corticosteroid doses vary by center-specific protocols, organ type, and patient characteristics. A typical taper would include an IV 100 to 500 mg bolus of methylprednisolone at the time of transplant and then a taper over 5 to 7 days to a maintenance dose of prednisone 20 mg/day or complete cessation.2,7 It is important for practitioners to know that approximately 4 mg methylprednisolone is equivalent to 5 mg prednisone and 0.75 mg dexamethasone.11 At most transplant centers, therapeutic drug monitoring of corticosteroids is not employed. Corticosteroids are associated with a variety of acute and chronic toxicides. The most common adverse events have been summarized in Table 52-5. 

Merle, Y. and Mentre, F. (1999) Optimal sampling times for Bayesian estimation of the pharmacokinetic parameters of nortriptyline during therapeutic drug monitoring. / Pharmacokinet Biopharm 27 85-101. 

Therapeutic drug monitoring, 101-110 analytical techniques, 105 by immunoassay, 158 choice of drug, 103 choice of sample, 103 indications for, 102 interpretation of results, 106 timing of measurements, 104 Thermal conductivity detector, 183 Thiabendazole, 85,1012 Thiacetazone, 1013 Thiacyl, 978 Thialbarbital, 1014 Thialbarbitone, 1014 Thialbarbitone sodium, 1014 Thiamazole, 750 Thiambutosine, 1014 Thiamine, 1014 in sport, 99... 

Schulte P. What Is an adequate trial with clozapine therapeutic drug monitoring and time to response in treatment-refractory schizophrenia. Clin Pharmacokinet 2003 42 607-f8. 

Time course of drug concentration Drug passage across cell membranes Order of reaction Plasma half-life and steady-state concentration Therapeutic drug monitoring... 

Ambrose, P.J. Nitake, M. Kildoo, C.W. Impact of pharmacist scheduling of blood-sampling times for therapeutic drug monitoring. Am. J. Hosp. Pharm. 1988, 45 (2),... 

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