Intravenous bolus administration monitoring drug in urine

8 Intravenous bolus administration monitoring drug in urine 

perhaps, a more convenient method of sample collection, and sample size is generally not a problem. The sampling time, however, reflects drug in urine collected over a period of time, rather than a drug concentration at a discrete time. 

Urinary data allows direct measurement of bioavailability, both absolute and relative, without the need of fitting the data to a mathematical model. 

If the administered drug is totally removed in the urine in unchanged (unmetabolized) form, then the excretion and elimination processes are synonymous then, the excretion rate 

Equations 3.16 and 3.17 clearly suggest that the cumulative mass of dmg excreted and/or eliminated into urine increases asymptotically with time, as illustrated in Fig. 3.14. 

---