Tacrolimus drug monitoring

Taylor, P.J. et al. 2000. Simultaneous quantification of tacrolimus and sirolimus in human blood by high performance liquid chromatography-tandem mass spectrometry. Ther Drug Monitor. 22 608. [Pg.317]

Armstrong, V.W., Oelleiich, M. (2001) New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine. Clin. Biochem. 34, 9-16. [Pg.74]

PROTEASE INHIBITORS CICLOSPORIN, SIROLIMUS, TACROLIMUS t levels with protease inhibitors Inhibition of CYP3A4-mediated metabolism of these immunomodulating drugs Monitor clinical effects closely and check levels... [Pg.615]

ACICLOVIR/ VALACICLOVIR ANTICANCER AND IMMUNOMODULATING DRUGS- 1. CICLOSPORIN 2. MYCOPHENOLATE 3. TACROLIMUS 1.1 nephrotoxicity 2. Possible T efficacy 3. t levels with protease inhibitors 1. Additive side-effect 2. Competition for renal excretion 3. Inhibition of CYP3A4-mediated metabolism of tacrolimus 1. Monitor renal function prior to concomitant therapy and monitor cidosporin levels 2. Monitor renal function particularly if on >4g valaciclovir 1 dose of aciclovir if there is a background of renal failure 3. Monitor clinical effects closely check levels... [Pg.628]

Oellerich M, Armstrong VW, Schutz E, Shaw LM. Therapeutic drug monitoring of cyclosporine and tacrolimus. Update on Lake Louise Consensus Conference on cyclosporine and tacrolimus. Clin Biochem 1998 31 309-16. [Pg.177]

Alak AM. Measurement of tacrolimus (FK506) and its metabohtes A review of assay development and application in therapeutic drug monitoring and pharmacokinetic studies. Ther Drug Monit 1997 19 338-51. [Pg.1280]

TrifUio SM, Scheetz MH, Pi J, Mehta J. Tacrolimus use in adult allogeueic stem cell trausplaut redpieuts receiving voriconazole preemptive dose modification and therapeutic drug monitoring. Bone Marrow Transplant 2010 45(8) 1352-6. [Pg.649]

Hoogtanders Ket al (2007) Therapeutic drug monitoring of tacrolimus with the dried blood spot method. J Pharm Biomed Anal 44 658-664... [Pg.13]

Key words Cyclosporine, Sirolimus, Tacrolimus, Mass spectrometry. Therapeutic drug monitoring... [Pg.167]

After transplantation, immunosuppression must be used to prevent host rejection of the graft liver, usually with prednisone and tacrolimus or cyclosporine. Tacrolimus and cyclosporine are calcineurin inhibitors and require drug level monitoring because of a narrow therapeutic range and significant toxicity, including renal failure and neurotoxicity. [Pg.403]

TACROLIMUS CO-TRIMOXAZOLE Exacerbates hyperkalaemia induced by tacrolimus Additive hyperkalaemic effects Monitor electrolytes closely >- For signs and symptoms of hyperkalaemia, see Qinical Features of Some Adverse Drug Interactions, Hyperkalaemia... [Pg.385]

TACROLIMUS ANTIHYPERTENSIVES AND HEART FAILURE DRUGS-ANGIOTENSIN II RECEPTOR ANTAGONISTS t risk of hyperkalaemia Uncertain Monitor serum potassium weekly until stable and then every 6 months... [Pg.387]

TACROLIMUS LIPID-LOWERING DRUGS -STATINS Single case report of rhabdomyolysis when simvastatin was added to tacrolimus Uncertain at present Monitor LFTs and CK closely warn patients to report any features of rhabdomyolysis... [Pg.388]

CHLORAMPHENICOL ANTICANCER AND IMMUNOMODULATING DRUGS-TACROLIMUS Toxic blood levels of tacrolimus, usually on the second day of starting chloramphenicol Attributed to impaired clearance of tacrolimus by chloramphenicol 1 dose of nearly 80% of tacrolimus may be required to prevent toxicity. Watch for adverse effects (see below). Monitor tacrolimus plasma concentrations... [Pg.549]

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