Drug delivery systems nanotechnologies

Li L, Chen D, Zhang Y et al (2007) Magnetic and flumescent multifunctimial chitosan nanoparticles as a smart drug delivery systems. Nanotechnology 18 405102. doi 10.1088/ 0957-4484/18/40/405102... 

Drew Harris, John MiUer, Raj Bawa, Janell T. Cleveland, and Sean O Neill, Strategies for resolving patent disputes over nanoparticle drug delivery systems. Nanotechnology Law and Business 1(4) 101-118 (2004). 

Motornov, M. et al. (2009) Switchable selectivity for gating ion transport with mixed polydectrolyte brushes approaching smart drug delivery systems. Nanotechnology, 20, 10. 

Some of their derivatives have been used as antiviral drugs. Due to their flexible chemistry, they can be exploited to design drug delivery systems and in molecular nanotechnology. In such systems, they can act as a central lipophilic core and different parts like targeting segments, linkers, spacers, or therapeutic agents can be attached to the said central nucleus. Their central core can be functionalized by peptidic and nucleic acid sequences and also by numerous important biomolecules. 

Table 22.1 Classification of nanotechnological drug delivery systems.

Volume 2 addresses the applications and approaches in advanced drug delivery systems, including transdermal, pulmonary, and ocular routes. In addition, this text discusses the impact of the shift to personalized medicines in the fields of pharmaceutical biotechnology, pharmacogenomics, and nanotechnology. 

Huge advances have been made over the last 15 years in the research, development, application, commercialization and understanding of the mechanisms of action of nanoscale drug delivery systems. Many of these advances have had a spectacular impact on the prevention, diagnosis and treatment of a wide range of diseases. This is especially trae in the treatment of many cancers, and it is in the oncology field that the majority of the formulation advances have been made. Pharmaceutically, the most important nanotechnologies are exemplified and discussed below (see Table 39.10 for definitions and descriptions). 

In the future, nanotechnology is likely to benefit many areas of medicine such as sensors for use in the laboratory or clinic and within the human body, new drug formulations, and novel drug-delivery systems. The most important potential uses of nanotechnology in medicine include the early detection and treatment of disease. 

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Yamazaki N, Kojima S, Yokoyama H (2005). Biomedical nanotechnology for active drug delivery systems by applying sugar-chain molecular functions. Curr. Appl. Phys. 5 112-117. 

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