Delivery nanotechnological system

In this chapter, we describe different nanotechnological systems for drug delivery and their potential applications for improved systemic and local bioavailability. The chapter is an overview that hopefully guides the interested reader to the more detailed texts on this issue. 

Rossi, F., Ferrari, R., Castiglione, F., Mele, A., Perale, G., MoscateUi, D., 2015b. Polymer hydrogel functionalized with biodegradable nanoparticles as composite system for controlled drug delivery. Nanotechnology 26, 015602. 

Some of their derivatives have been used as antiviral drugs. Due to their flexible chemistry, they can be exploited to design drug delivery systems and in molecular nanotechnology. In such systems, they can act as a central lipophilic core and different parts like targeting segments, linkers, spacers, or therapeutic agents can be attached to the said central nucleus. Their central core can be functionalized by peptidic and nucleic acid sequences and also by numerous important biomolecules. 

Kono K. Apphcation of dendrimers to dmg delivery systems—from the view point of carrier design based on nanotechnology. Dmg Deliv Syst 2002 17 462-470. 

Prodrugs definitely will lead the way in novel delivery systems addressing the need for precise targeting and efficient delivery of cancer chemotherapeutics. The understanding of cellular mechanisms and continued advances in nanotechnology, material science, and engineering will continue to drive innovation in this field. 

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