Doxorubicin drug resistance

Lucci, A., Han, T. Y., Liu, Y. Y., Giuliano, A. R, and Cabot, M. C., 1999b, Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells. Cancer 86 299-310. 

Killion JJ, Beltran P, O Brian CA, Yoon SS, Fan D, Wilson MR, Fidler IJ (1995) The antitumor activity of doxorubicin aganist drug-resistant murine cardnom is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251. Oncol Res 7 453-459... 

Anthracyclines are antitumor quinone containing antibiotics produced by different strains of Streptomyces. Some of them, such as adriamycin doxorubicin), and daunorubicin are broad spectrum antitumor compounds. They act by binding to DNA and interfering with DNA replication and gene transcription. Their limitations for clinical use are cardiac toxicity and drug resistance phenomena. Consequently, intense structure-activity relationship studies have been performed to improve the pharmacological profile as well as to enhance the affinity for DNA. In particular, a number of fluorinated anthracyclines have been prepared with introduction of fluorine atoms into D or A cycles, and into the aglycone side chain linked atC-14. ... 

Based on the same principle of modulation of drug absorption, other less known botanicals could produce similar or different effects compared to St. John s wort. Rosemary (Rosemarinus officinalis Labiatae) is a commonly used dietary botanical that has been found to have a chemopreventive effect (24). Furthermore, in drug-resistant MCF-7 human breast cancer cells expressing P-glycoprotein, methanol extracts of Rosemary at two concentrations (16.5 and 85 pg/mL) inhibited the efflux and increased intracellular accumulation of doxorubicin and vinblastine, two chemotherapeutic drugs that are known substrates of P-glycoprotein. Treatment of drug-resistant cells with the extracts also increased the cytotoxic effects of doxorubicin. On the other hand, in wild-type MCF-7 cells that do not express... 

Challenge Problem Doxorubicin (DOX) is a widely used anthracycline that has been effective in the treatment of leukemia and breast cancer in humans (A. B. Anderson, C. M. Ciriaks, K. M. Fuller, and E. A. Ariaga, Anal. Chem., 2003, 75, 8). Unfortunately, side effects such as liver toxicity and drug resistance have been reported. In a recent study, Anderson et al. used laser-induced fluorescence (LIF) as a detection mode for capillary electrophoresis to investigate metabolites of DOX in single cells and subcellular fractions. The following are results similar to those obtained by... 

Bennis, S. Chapey, C. Couvreur, R Robert, J. Enhanced cytotoxicity of doxorubicin encapsulated in polyhexylcyanoacrylate nanospheres against multi-drug-resistant tumour cells in culture. Eur. J. Cancer 1994, 30A, 89-93. 

Thierry, A. R., Vige, D., Coughhn, S. S., Belh, J. A., Dritscilo, A., Rahman, A. Modulation of doxorubicin resistance in multi-drug resistant cells by liposomes. FASEB J. 1993, 7, 572—579. 

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