Doubling dose

Therefore we should expect in the gaseous state to find molecules such as BeH2 and BeF2. These molecules have been detected. On the other hand, beryllium has the trouble boron has, only in a double dose. It has two vacant valence orbitals. As a result, BeH2 and BeF2 molecules, as such, are obtained only at extremely high temperatures (say, above 1000°K). At lower temperatures these vacant valence orbitals cause a condensation to a solid in which these orbitals can participate in bonding. We shall discuss these solids in the next chapter. 

Cautions not to double dose if dose is missed but to skip dose and resume treatment Hie next day. 

Continuous IV infusion regimen 0.0005 units/kg/h double dose as needed every 30 min to a maximum of 0.01 units/kg/h... 

The empiric use of a standard-dose (or double-dose) PPI as a therapeutic trial may be used in diagnosing GERD. This approach is less expensive, more convenient, and more readily available than ambulatory pH monitoring. Problems with this diagnostic approach include lack of a standardized dosing regimen and duration of the diagnostic trial. 

Accidental overdose (usually Atropine sulfate is recommended antidote double-dosed), 60 mg/kg BW LABORATORY WHITE RAT, Rattus sp. Dermal Single application, mg/kg BW 23... 

I was lying on the court, my knee locked in a slightly flexed position. Sitting there, unable to get up right away, I knew a double dose of bad luck had struck. I surely wasn t going to play any more tennis for a while. Worse, the accident came just as I was preparing to conduct a rntgor indoor field test with BZ. 

Note that, to call attention to an important source of variability in the onset time, we used the term dose onset factor (Donset). As stated, it represents the decrease in Tonso, (the time at which NF performance first falls below 25% of baseline) when the incapacitating dose (IDso) is doubled. In the case of BZ, for example, doubling the absorbed dose shortens the Tonso from four hours to less than an hour. Doubling it again presumably shortens it to just a few minutes. This would be an important concept for military plarmers to consider. Our data were insufficient to measure the Domet precisely because we preferred not to administer double doses to volunteers, hr the few cases in which actual aerosol doses were considerably higher than the intended value, however, the dramatically earlier onset of incapacitation allowed an educated guess of the Donset. 

Fig. 4.1 Plasma concentration profiles after doubling doses showing (a) proportional increase with dose,...

Concerns about safety of the study drug may characterise the Japanese clinical trial, in a Phase 1 study, the dose escalation stops at the level of expected therapeutic dose or double dose of it, and is never escalated to identify any toxicity (except for anticancer drugs), if toxicity is observed in a Phase I study, even if it is at the highest dose or under experimental conditions, further study will be difficult. Everybody in the clinical trial is used to handle study drugs with no safety problems and there is the general concept that the drug must be safe. ... 

Heart failure PO Initially, 4 mg once daily. May double dose at approximately 2-wk... 

Congestive heart failure PO (Extended-Release) Initially, 25 mg/day. May double dose q2wk. Maximum 200 mg/day. 

Hyperlipidemia PO (Immediate-Release) Initially, 50-100mgtwiceadayfor7days. Increasegradually by doubling dose qwkup to 1-1.5 g/day in 2-3 doses. Maximum 3 g/day. PO (Niaspan) Initially, 500 mg/day at bedtime for 4 weeks then increase to 1,000 mg/day at bedtime. Maximum dose 2,000 mg/day at bedtime. 

CHF PO, IV Initially, 10-20 mg/day. May increase by approximately doubling dose until desired therapeutic effect is attained. Doses greater than 200 mg have not been adequately studied. 

It is N-methylphenobarbitone. It is more expensive than phenobarbitone and requires double dose compared to phenobarbitone. It probably offers no advantage over phenobarbitone. 

Mercadante, S., Arcuri, E.f Tirelli, W.-, Casuccio, A. Analgesic effect of intravenous ketamine in cancer patients on morphine therapy a randomized, controlled, double-blind, crossover, double-dose study, J. Pain Symptom. Manage. 2000, 20, 246-252. 

The effect of increasing doses of mometasone furoate and fluticasone propionate by dry powder inhaler on adrenal function was studied by using overnight urinary cortisol in 21 patients with asthma (55). Patients were randomized in a crossover fashion to receive 2-weekly consecutive doubling doses of either fluticasone propionate (500, 1000, and 2000 micrograms/day) or mometasone furoate (400, 800, and 1600 micrograms/day). Both treatments were... 

Either one double dose of the levonorgestrel regimen (1.5 mg) or the regular two-dose levonorgestrel regimen (0.75 mg each dose) can be used, as they have similar efficacy with no difference in adverse effects. 

Lower curve (rat 183). Effect of a double dose of angiotonin mixed with amine oxidase and shaken for 30 minutes at room temperature. Angiotonin was completely inactivated. After 4 minutes the same dose alone produced a modified pressor response. Rat was hypertensive. 

Water in the swimming pool and snow on the ski slopes reflect sun s rays. At the same time, the swimmers and skiers absorb the sun s rays that strike them. Therefore, they get a double dose of energy from the sun. 

The timing of medication is critical in ulcer therapy. Anticholinergic drugs should be given about 30 min before meals and antacids about 1 h after meals. A double dose of an antacid is often taken just before bedtime. 

Immediate reduction needed very rare. Nipride never fails (5). Take BP every two minutes. Infuse with pump Nipride (mix as per instructions). Double dose every two minutes till BP falls, then back down to 1/2 of last step up and adjust till at goal—usually takes about 30 minutes to stabilize. Add oral agents as given in the table. 

Dermal Effects. Administration of 0.04 mg chromium(VI)/kg as potassium dichromate in an oral tolerance test exacerbated the dermatitis of a building worker who had a 20-year history of chromium contact dermatitis. A double dose led to dyshidrotic lesions (vesicular eruptions) on the hands (Goitre et al. 1982). Dermatitis in 11 of 31 chromium-sensitive individuals worsened after ingestion of 0.036 mg chromium(VI)/kg as potassium dichromate (Kaaber and Veien 1977). The sensitizing exposures were not discussed or quantified. 

Also technical aspects may contribute to the variable incidence of parenchymal enhancement in acute human stroke. With double dose contrast medium and a time lag between injection and imaging, every fourth stroke patient showed tissue enhancement within 24 h of stroke onset (Karonen et al. 2001). Widespread parenchymal enhancement in Tl-w images seems to gradually develop over the first week when simultaneously the diffusion changes tend to pseudonormalize. Without precise clinical history confounding with tumor enhancement may occur and should be ruled out by observation of the time profile of MR contrast enhancement and DWI. 

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