Dose response double-blind crossover study

Rowe KS Synthetic food colourings and hyperactivity a double-blind crossover study. Australian Paediatric Journal 24 143-147,1988 Rowe KS, Rowe KJ Synthetic food coloring and behavior a dose response effect in a double-blind, placebo-controlled, repeated-measures study. J Pediatr 125 691-698, 1994... 

It has been suggested that calcium channel blockers can be used to treat cocaine dependence, and some studies have shown reductions in cocaine-induced subjective and cardiovascular responses with nifedipine and diltiazem. The cardiovascular and subjective responses to cocaine have been evaluated in a double-blind, placebo-controlled, crossover study in five subjects pretreated with two dosage of nimodipine (393). Nimodipine 60 mg attenuated the rise in systolic, but not diastolic, blood pressure after cocaine. In three subjects nimodipine 90 mg produced greater attenuation than 60 mg. The subjective effects of cocaine were not altered by either dose of nimodipine. 

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