Dopamine D, receptor agonists

Grondin, R. Bedard, P.J. Britton, D.R. Shiosaki, K. (1997) Potential therapeutic use of the selective dopamine D, receptor agonist, A-86929 an acute study in parkinsonian levodopa-primed monkeys. Neurology 49, 421-426. 

Experimental Dopamine D, Receptor Agonists. The opposing actions of the direct and indirect pathways in the basal ganglia (see Fig. 12.1) suggest that coordinated movement requires neurotransmission to be activated in... 

Bagetta G., Sarro G. D., Priolo E., Nistico G. (1988). Ventral tegmental area site through which dopamine D2-receptor agonists evoke behavioral and electrocortical sleep in rats. Br. J. Pharmacol 95, 860-6. 

Khroyan T.V., Platt D.M., Rowlett J.K., Spealman R.D. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology (Berlin). 168 124, 2003. 

In vitro studies suggest that the GRK4 SNPs impair the function of receptors, increase blood pressure, and impair the diuretic and natriuretic effects of dopamine Dj-like agonist stimulation. Inappropriate desensitization of the dopamine D, receptor in renal proximal tubules in hypertension may result in the decreased ability of the kidney to eliminate a sodium chloride load—a key risk factor in the development of hypertension. 

Ng, G. Y., Trogadis, J., Stevens, J., Bonvier, M., O Dowd, B. F., and George, S. R. (1995) Agonist-induced desensitization of dopamine D receptor-stimnlated adenylyl cyclase activity is temporally and biochemically separated from D receptor internalization. Proc. Natl. Acad. Sci. U. S. A. 92, 10157-10161. 

D Aquila PS, Collu M, Pani L, et al Antidepressant-hke effect of selective dopamine Dj receptor agonists in the behavioural despair animal model of depression. Eur J Pharmacol 262 107-111, 1994... 

Fenoldopam is a peripheral arteriolar dilator used for hypertensive emergencies and postoperative hypertension. It acts primarily as an agonist of dopamine D receptors, resulting in dilation of peripheral arteries and natriuresis. The commercial product is a racemic mixture with the (R)-isomer mediating the pharmacologic activity. 

Mercier D, Falardeau P, Levesque D (2001) Autoreceptor preference of dopamine D2 receptor agonists correlates with preferential coupling to cyclic AMP. Neuroreport 72 1473-1479. 

Akunne HC, Towers P, Ellis GJ, Dijkstra D, Wikstrom H, Heffner TG, Wise LD, Pugsley TA (1995) Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells. Life Sci 57 1401-1410. 

Seiler, M.P. and Markstein, R. (1982) Further characterization of structural requirements for agonists at the striatal dopamine D receptor. Studies with a series of monohydroxyaminotetralins on dopamine-sensitive adenylate cyclase and a comparison with dopamine receptor binding. Mol. Pharmacol. 22,281-289. 

Spealman, R.D. (1996) Dopamine D3 receptor agonists partially reproduce the discriminative stimulus effects of cocaine in squirrel monkeys. J. Pharmacol. Exp. Ther. 278, 1128-1137. 

The pharmacodynamically complex profile of the ergolines as ligands for serotonin (5-HT) receptors, dopamine (D) receptors, and adrenoceptors, respectively, is explainable by the fact that these alkaloids include the essential structural features of the corresponding three monoamine neurotransmitters. This can be visualized by superimposition of the ergoline skeleton by these three natural agonists each (Fig. 4.9). 

Figure 2 A scheme of our proposed dopamine D-2 agonist receptor map. The fine dots enclose the accessible region and the heavy dots show one forbidden region. Tlte two acetate groups are proposed receptor groups.

DM Mottola, S Laiter, VJ Watts, A Tropsha, SW Wyrick, DE Nichols, P Mailman. Conformational analysis of d dopamine receptor agonists Pharmacophore assessment and receptor mapping. J Med Chem 39 285-296, 1996. 

Monti J., Hawkins M., Jantos H., DAngelo L., Fernandez M. (1988). Biphasic effects of dopamine D-2 receptor agonists on sleep and wakefulness in the rat. 

Self D., Barnhart W., Lehman D., Nestler E. Opposite modulation of cocaine-seeking behavior by Dl- and D2-like dopamine receptor agonists. Science. 271 1586, 1996. 

The answer is d. (Hardman, pp 1371-13720 High prolactin levels in the serum result in amenorrhea, for reasons that are not known. Bromocriptine inhibits prolactin secretion through its dopaminergic action This compound, a semisynthetic ergot derivative, appears to be a dopamine receptor agonist. It is administered orally to the patient and, in most cases, menses occurs after a month of therapy. 

Saurer, T. B. et al., Morphine-induced alterations of immune status are blocked by the dopamine D-2-like receptor agonist 7-OH-DPAT, J. Neuroimmunol., 148, 54, 2004. 

Rodriguez, D. F. et al., The dopamine receptor agonist 7-OH-DPAT modulates the acquisition and expression of morphine-induced place preference, Eur. J. Pharmacol., 21 A, 47, 1995. 

Dougall, I.G., Young, A., Ince, F., and Jackson, D.M., Dual dopamine D2 receptor and / -adrenoceptor agonists for the treatment of chronic obstructive pulmonary disease the pre-clinical rationale, Resp. Med., 97, S3, 2003. 

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