DOP test

Cold-generated DOP A cold-generated aerosol dioctylphthalate (DOP) test, used to measure the efficiencies of high-efficiency filters. A hot DOP test may also be used. 

DOP test records of HEPA filters and revalidation records... 

Although the results of nonviable particles were found within limits, the DOP test records were still checked and found satisfactory. The air velocity records were reviewed in each critical room during mn 1, run 2, and run 3 and found within tolerance. See SOP (number). 

HEPA FILTER LEAK (DOP) TEST RESULTS Company Name... 

Filters used for the prefiltration and final filtration should be maintained to operate to their design specifications. Deterioration of filters is caused by leakage and/or accumulation of particles. The former is tested by periodical integrity test (usually dioctylphthalate DOP test), and the latter is tested by the increase of air pressure differentials between the upstream and downstream sides of the fdter. 

Smoke DOP Test. The classic method for determining the filtration efficiency of various air filters is to challenge the filter with a liquid aerosol of dioctyl phthalate (DOP). Typically, the aerosol particles are 0.3 ju in diameter. 

The leak test ( DOP test situ test to verify that filters do not leak on inatidlation. The leak test is not a second efficiency test. It is intended to dis> close leaks around the frames and damage to the filter medium. An aerosol of oil particles with mass median diameter of 0.3 pm is used to challenge the filter deteaion Is by aerosol photometry on the downstream side. Standards of integrity are specified as maximum permissable percentages of the upstream concentration of particles that can be recovered downstream of the filler. 

Upon installation, HEPA filters shall be integrity tested by a suitable method, e.g., cold DOP test... 

DOP (Dioctylphthalate) Generated particles of this chemical are used in filter efficiency tests. 

Efficiency testing of high-efficiency partieulate air (HEPA) filters used for the supply of sterile air to aseptie workplaces (Chapter 22) is normally achieved by the generation upstream of dioetylphthalate (DOP) or sodium ehloride particles of known dimension, followed by deteetion in downstream filtered air. Retention efficiency is reeorded as the percentage of partieles removed under defined test conditions. Microbiological tests are not normally performed. 

The recommended air velocity of a HEPA filter is 0.45 m/s. The HEPA filter and its housing must be tested mounted on site with the DOP. Eor return openings for powder production, the housing with HEPA filter must be fitted with a prefilter removable from the front. The recommendation is to use HEPA filter presealed in the housing located in a stainless steel frame. 

Introduce DOP aerosol upstream of the filter through a test port and search for leaks downstream with an aerosol photometer. Filter testing shall be performed after operational air velocities have been verified and adjusted where necessary. 

DOP has also heen used in Swedish expls and propints- Their specification requirements and tests are described in Ref 5... 

Finally, a recently published draft report of a National Toxicology Program study found DOP (or DEHP as it is referred to in toxicology studies) to be carcinogenic to certain strains of mice and rats when fed at very high levels in the diet for the lifetime of the test animals. It may be a number of years before the mechanism of the induced carcinogenic effects can be understood, and a realistic assessment of any risk to man can be made. The final version of the draft report is expected to issue in February, 1981. 

Individual HEPA filter efficiencies are established by an exacting challenge of the filter frame and medium, usually incorporating a cold-boil, polydisperse aerosol of dioctylpthalate (DOP) or equivalent, which is introduced into the upstream plenum-side of the filter in a manner that ensures even distribution of the test aerosol behind the filter, at its rated airflow. 

Luks-Betlej et al. evaluated six different fiber materials for determination of seven different phthalates in water samples [56]. The tested phthalates included DMP, DEP, di-n-butyl phthalate (DBP), BBP, DEHP, di-n-octyl phthalate (DOP) and di-n-nonyl phthalate (DNP). All fibers investigated were favorable for the extraction of BBP. Low molecular weight phthalates (DMP, DEP, DBP) were best extracted by DVB/CAR/PDMS, DBP by CW/DVB and DEHP by PDMS fiber. CW/DVB fiber gave the best repeatability. Application of CW/DVB fibers to different water samples allowed the detection of... 

Integrity test all HEPA filters with dioctylphthalate (DOP) smoke (0.3 ft). 

HEPA filters are 99.99% efficient when tested with DOP smoke. 

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