DNA walker

Yin P, Yan H, Daniell XG, Turberfield AJ, Reif JH (2004) A unidirectional DNA walker that moves autonomously along a track. Angew Chem Int Ed 43 4906-4911... 

He Y, Liu DR (2010) Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker. Nature Nanotechnol 5 778-782... 

By the cyclic interaction of the QD-DNA walker-scaffold system with AMP or adenosine deaminase, the walker unit was reversibly cycled between footholds (27) and (28), resulting in efficient and less-effident FRET processes, respectively (Figure 6.22b). 

Nano-devices that have been reported include strand displacement reactions that respond to enviromnental stimuli, a pH responsive strand displacement reaction that translocates along a target sequence (DNA walker), and a series of DNA logic gates that create a digital circuit comprising 130 DNA strands. ... 

Delwart EL, Sheppard HW, Walker BD, Goudsmit J, Mullins J1 (1994) Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobUity assays, J Vhol 68 6672-6683... 

Walker, J.C., Howard, E.A., Dennis, E.S. Peacock, W.J. (1987). DNA sequences required for anaerobic expression of the maize Alcoholdehydrogenase-l gene. Proceedings of the National Academy of Sciences, USA, 94, 6624-8. 

Walker, G. T., et al. (1992). Strand displacement amplification—an isothermal, in vitro DNA amplification technique. Nucleic Acids Res. 20, 1691-1696. 

Friedberg EC, Walker GC, Siede W (1995) DNA repair and mutagenesis. ASM Press, Washington... 

Elephantopus mollis is interesting because it elaborates a series of cytotoxic antitumor germacranolides including molephantinin and phantomolin, which are cytotoxic in vitro and in vivo against Ehrlich ascites carcinoma and Walker 256 carcinosarcoma in rodents (104,105). Molephantinin mitigates DNA and protein synthesis in Ehrlich ascites carcinoma cells and DNA synthesis. What is the activity of molephantinin on apoptosis (106)1... 

Knorr V, Allmendinger L, Walker GF, Paintner FF, Wagner E (2007) An acetal-based PEGylation reagent for pH-sensitive shielding of DNA polyplexes. Bioconjug Chem 18 1218-1225... 

Colquhoun and Schumacher [98] have shown that y-linolcnic acid and eicosapentaenoic acid, which inhibit Walker tumor growth in vivo, decreased proliferation and apoptotic index in these cells. Development of apoptosis was characterized by the enhancement of the formation of reactive oxygen species and products of lipid peroxidation and was accompanied by a decrease in the activities of mitochondrial complexes I, III, and IV, and the release of cytochrome c and caspase 3-like activation of DNA fragmentation. Earlier, a similar apoptotic mechanism of antitumor activity has been shown for the flavonoid quercetin [99], Kamp et al. [100] suggested that the asbestos-induced apoptosis in alveolar epithelial cells was mediated by iron-derived oxygen species, although authors did not hypothesize about the nature of these species (hydroxyl radicals, hydrogen peroxide, or iron complexes ). 

Seiler-Tuyns A, Walker P, Martinez E, Merillat AM, Givel F, Wahli W (1986) Identification of estrogen-responsive DNA sequences by transient expression experiments in a human breast cancer cell line. Nucleic Acids Res 14 8755... 

J. C. Walker, E. A. Howard, E. S. Dennis, W. J. Peacock (1987) DNA sequences required for anaerobic expression of the maize alcohol dehydrogenase I gene. Proc. Natl. Acad. Sci. USA, 84 6624-6628... 

There was no increase in mutation frequency at the hypoxanthine-guanine phosphoribosyl transferase gene locus in the presence or absence of S9 (Bootman et al. 1988b), and results were negative in a DNA repair assay with E. coli (Hodson-Walker and May 1988). 

Hodson-Walker, G. and K.May. 1988. CFC141b Assessment of its ability to cause lethal DNA damage in strains of Escherichia coli. 88PSV008/258, Life Science Research Ltd., EYE, Suffolk, England (Cited in ECETOC 1994). 

Mouse lymphoma (DNA strand breaks) Chromosomal aberration No data — Pellack-Walker and Blumer 1986... 

Pellack-Walker P, Blumer JL. 1986. DNA damage in L5178YS cells following exposure to benzene metabolites. Mol Pharmacol 39 42-47. 

P. Pellack-Walker, J. K. Walker, H. H. Evans, J. L. Blumer, Relationship between the Oxidation Potential of Benzene Metabolites and Their Inhibitory Effect on DNA Synthesis in L5178YS Cells , Mol. Pharmacol. 1985, 28, 560 - 566. 

Walker, U.A. et al. (2004) Depletion of mitochondrial DNA in liver rmder antiretroviral therapy with didanosine, stavudine, or zalcitabine. Hepatology,... 

DIA, DNA strand breaks, mouse lymphoma L5178YS eells in vitro - NT 110 Pellaek-Walker Blumer ... 

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